产品货号 : jlcR18313 英文名称 : LMO1 中文名称 : T淋巴细胞转运蛋白1抗体 别 名 : Cysteine rich protein TTG 1; Cysteine rich protein TTG1; LIM domain only 1; LIM domain only protein 1; LMO 1; MGC116692; RBTN 1; RBTN1; RHOM 1; RHOM1; Rhombotin 1; Rhombotin1; T cell translocation protein 1; TTG 1; TTG1. 研究领域 : 细胞生物 转运蛋白 淋巴细胞 t-淋巴细胞 表观遗传学 抗体来源 : Rabbit 克隆类型 : Polyclonal 交叉反应 : Human, Mouse, Rat, Chicken, Pig, Cow, Rabbit, Zebrafish, Guinea Pig, Monkey, Cat, Spider Monkey 产品应用 : WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复) not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. 分 子 量 : 18kDa 细胞定位 : 细胞核 性 状 : Lyophilized or Liquid 浓 度 : 1mg/ml 免 疫 原 : KLH conjugated synthetic peptide derived from human LMO1:1-80/156 亚 型 : IgG 纯化方法 : affinity purified by Protein A 储 存 液 : 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. 保存条件 : Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. PubMed : PubMed 产品介绍 : This locus encodes a transcriptional regulator that contains two cysteine-rich LIM domains but lacks a DNA-binding domain. LIM domains may play a role in protein interactions; thus the encoded protein may regulate transcription by competitively binding to specific DNA-binding transcription factors. Alterations at this locus have been associated with acute lymphoblastic T-cell leukemia. Chromosomal rearrangements have been observed between this locus and at least two loci, the delta subunit of the T-cell antigen receptor gene and the LIM domain binding 1 gene. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2012]
Function: May be involved in gene regulation within neural lineage cells potentially by direct DNA binding or by binding to other transcription factors.
Subcellular Location: Nuclear
Tissue Specificity: Expressed mainly in the central nervous. Low level of expression in other tissues including thymus.
DISEASE: A chromosomal aberration involving LMO1 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(11,14)(p15;q11) with TCRD.
Similarity: Contains 2 LIM zinc-binding domains.
SWISS: P25800
Gene ID: 4004
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.