重组人IL-36γ(169a.a.)北京厂家

特别提示：包括重组人IL-36γ(169a.a.)在内，本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！

产品名称：重组人IL-36γ(169a.a.)
英文名称：Recombinant Human Interleukin-36 gamma, 169a.a.
产品货号：GS4660
产品规格：2μg

分子量：Approximately 18.7kDa,a single non-glycosylated polypeptide chain containing 169 amino acids.
储存条件：冷冻（-20℃）

概述

Interleukin-36(IL-36)is a pro-inflammatory cytokine which plays an important role in the pathophysiology of several diseases.IL-36α,IL-36β,and IL-36γ(formerly IL-1F6,IL-1F8,and IL-1F9)are IL-1 family members that signal through the IL-1 receptor family members IL-1Rrp2(IL-1RL2)and IL-1RAcP.IL-36γ is secreted when transfected into 293-T cells and it could constitute part of an independent signaling system analogous to interleukin-1 alpha(IL-1A),beta(IL-1B)receptor agonist and interleukin-1 receptor type I(IL-1R1).Furthermore,IL-36γ also can function as an agonist of NF-kappa B activation through the orphan IL-1-receptor-related protein 2.Recombinant human IL-36γ is synthesized as a 19 kDa,169 amino acid(a.a.)protein that contains no signal sequence,no prosegment and no potential N-linked glycosylation site.Human to mouse,IL-36γ shares 53%a.a.identity.Within the family,IL-36γ shares about 25%~55%a.a.sequence identity with IL-1RA,IL-1β,IL-36RA,IL-36α,IL-37,IL-36β and IL-1F10.

使用说明

This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.

技术规格
 

外观	Sterile Filtered White lyophilized(freeze-dried)powder.
纯度	＞95%by SDS-PAGE and HPLC analyses.
来源	Escherichia coli.
生物活性	Fully biologically active when compared to standard.The specific activity is determined by its binding ability in a functional ELISA.Immobilized rHuIL-36γ at 1μg/mL can bind recombinant human IL-1 Rrp2 Fc Chimera with a range of 0.15-5 μg/mL.
成分	Lyophilized from a 0.2μmfiltered concentrated solution in PBS,pH 7.4.
内毒素	Less than 1 EU/μg of rHuIL-36γ,169a.a.as determined by LAL method.
复溶	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.Reconstitute in sterile distilled water or aqueous buffer containing 0.1%BSA to a concentration of 0.1-1.0mg/mL.Stock solutions should be apportioned into working aliquots and stored at ≤ -20?C.Further dilutions should be made in appropriate buffered solutions.
氨基酸序列	MRGTPGDADG GGRAVYQSMC KPITGTINDL NQQVWTLQGQ NLVAVPRSDS VTPVTVAVIT CKYPEALEQG RGDPIYLGIQ NPEMCLYCEK VGEQPTLQLK EQKIMDLYGQ PEPVKPFLFY RAKTGRTSTL ESVAFPDWFI ASSKRDQPII LTSELGKSYN TAFELNIND

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