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- 2025年12月05日
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- 详细信息
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
28808-62-0
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥777.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥304.0 |
| 规格： | 5 mg | 产品价格： | ￥800.0 |
| 规格： | 10 mg | 产品价格： | ￥1200.0 |
| 规格： | 25 mg | 产品价格： | ￥2180.0 |
| 规格： | 50 mg | 产品价格： | ￥3268.0 |
| 规格： | 100 mg | 产品价格： | ￥4903.0 |
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Fraxinellone
CAS No. : 28808-62-0
MCE 国际站：Fraxinellone
产品活性：Fraxinellone 是从芸苔科植物 Dictamnus dasycarpus 的根皮中分离出来的。 Fraxinellone 是 PD-L1 抑制剂，可抑制 HIF-1α 蛋白质合成，而不会影响 HIF-1α 蛋白质降解。 Fraxinellone 通过靶向 PD-L1，有用于癌症免疫的潜能。
研究领域：Immunology/Inflammation | Metabolic Enzyme/Protease | JAK/STAT Signaling | Stem Cell/Wnt
作用靶点：PD-1/PD-L1 | HIF/HIF Prolyl-Hydroxylase | STAT
In Vitro: Fraxinellone (0-100 μM；12 hours) decreases the percent of PD-L1 positive cells from 20.4% to 11.4% in A549 cells.
In Vivo: Fraxinellone (oral gavage; 30 and 100?mg/kg; every three days; 30 days) significantly suppresses tumor growth, reduces HIF-1α, pTyr705 STAT3, PD-L1 and VEGF staining compared with the control group in female athymic BALB/c nude mice.
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