STING agonist-3 trihydrochlori

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STING agonist-3 trihydrochloride

CAS No. :

MCE 国际站：STING agonist-3 trihydrochloride

产品活性：STING agonist-3 trihydrochloride 源于专利 WO2017175147A1 (实施例10)，是一种选择性和非核苷酸的小分子 STING 激动剂，pEC₅₀ 和 pIC₅₀ 分别为 7.5 和 9.5。STING agonist-3 trihydrochloride 具有持久的抗肿瘤作用，并且在改善癌症研究方面具有巨大潜力。

研究领域：Immunology/Inflammation

作用靶点：STING

In Vitro: STING agonist-3 trihydrochloride exhibits a pEC₅₀ value of 7.5 in activation of STING in cells, this assay is determined using a luciferase reporter assay in human embryonic kidney cells (HEK293T) co-transfected with plasmids expressing STING and the enzyme firefly luciferase driven by the interferon stimulated response element promoter.
STING agonist-3 trihydrochloride exhibits a pIC₅₀ value of 9.5 in FRET assay. This is a competition binding assay which aims to determine the binding potency of molecules to the C-terminal Domain (CTD) of human STING.

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