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-20°C, sealed storage, away from moisture
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货期：1-2天
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MedChemExpress LLC
- CAS号：
51116-01-9
- 规格：
10 mM * 1 mL/5 mg/10 mg/25 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥770.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥700.0 |
| 规格： | 10 mg | 产品价格： | ￥1100.0 |
| 规格： | 25 mg | 产品价格： | ￥2200.0 |
| 规格： | 50 mg | 产品价格： | ￥3500.0 |
| 规格： | 100 mg | 产品价格： | ￥5800.0 |
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8-Bromo-cGMP sodium
CAS No. : 51116-01-9
MCE 国际站：8-Bromo-cGMP sodium
产品活性：8-Bromo-cGMP sodium 是 cGMP 的膜渗透性类似物，是一种 PKG 激活剂。8-Bromo-cGMP sodium 可显着抑制 Ca2+ 宏观电流并损害高 K+ 刺激的胰岛素释放。8-Bromo-cGMP sodium 具有缓解疼痛和血管舒张作用。
研究领域：Membrane Transporter/Ion Channel | Neuronal Signaling
作用靶点：Calcium Channel
In Vitro: 8-Bromo-cGMP sodium (1-100 μM; 8 h) increases resistance of LLC-PK1 cells to CsA toxicity concentration-dependently.
8-Bromo-cGMP sodium (1-100 μM; 16 h) induces the synthesis of HO-1 protein in a concentration-dependent fashion.
In Vivo: 8-Bromo-cGMP sodium (0.3, 1, 3.0 nmol; intrathecal administration; 10 min before test) dose-dependently and significantly increases the tail-flick latency in Vincristine-treated mice to the level observed in vehicle-treated naive mice (male ICR mice, 4weeks of age and weighing 20 g). Vincristine (0.05 mg/kg 1 day after the pre-drug tail-flick latency, and then 0.125 mg/kg twice a week for 6 weeks) can induce painful neuropathy in mice.
8-Bromo-cGMP sodium (10 mg/kg; iv; single dose) results in vasodilator responses in eNOS-Tg mice and WT littermates in C57BL/6 background (19-35 g).
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文献和实验Real-Time In Vivo Proteomic Identification of Novel Kinase Substrates in Smooth Muscle
in calcium desensitization. Using ileum smooth muscle, we metabolically labeled the muscle with (32 P)-orthophosphate, permeabilized the muscle, established constant calcium concentrations, and stimulated with 8-bromo-cGMP, which activates PKG. Proteins
96-well RNA In Situ Hybridization Protocol
8. Carefully remove cover, then add 100ul warm wash buffer and place plate on vacuum manifold (Millipore MAVM 096 01). 9. Turn vacuum to LOWEST setting, press on top of plate to form seal. Once the last bit of hybridization buffer has been removed
性细胞表面抗原结合来进行的。根据分离的靶细胞类型和靶物质用途的不同，有不同的方法可供选择，而按照应用领域的不同可以将Dynabeads分为研究级Dynabeads、临床用的无菌Dynabeads、体外治疗用的cGMP级Dynabeads。所有的Dynabeads在保存靶细胞的存活力和增殖力方面的质量是相同的。您可以选择即用型Dynabeads-已包被针对某种特异细胞群的一抗，或者选用用户型Dynabeads，用户需将自己选用的特异抗体包被在上面。这一过程并不需要经过离心或昂贵的柱分离，而只需一台磁分离器即可
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