- ￥600 - 1000
- MedChemExpress(MCE)
- 美国
- HY-108540
- 2025年12月05日
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
4°C, sealed storage, away from moisture
- 英文名：
2-Amino-2-norbornanecarboxylic acid; LAT1-IN-1
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
20448-79-7
- 规格：
10 mM * 1 mL/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥660.0 |
|---|---|---|---|
| 规格： | 50 mg | 产品价格： | ￥600.0 |
| 规格： | 100 mg | 产品价格： | ￥1000.0 |
MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。
BCH
CAS No. : 20448-79-7
MCE 国际站：BCH
产品活性：BCH (2-Amino-2-norbornanecarboxylic acid) 是 L 型氨基酸转运蛋白 1 (LAT1) 的选择性竞争性抑制剂，可显著抑制细胞对氨基酸的摄取和 mTOR 磷酸化，从而抑制癌细胞生长并诱导细胞凋亡。
研究领域：Apoptosis
作用靶点：Apoptosis
In Vitro: BCH (1-100 mM; 3 days; KYSE30 and KYSE150 esophageal cancer cells) treatment suppresses cell proliferation in a dose-dependent manner.
BCH (30 mM; 24 and 48 hours; KYSE30 and KYSE150 cells) treatment significantly increases cell population in the G0/G1 phase in both KYSE30 and KYSE150 cells, indicating that BCH induces cell cycle arrest at G1 phase.
BCH (30 mM; 0-24 hours; KYSE30 and KYSE150 cells) treatment decreases phosphorylation of 4E-BP1 and p70S6K at 30 minutes and the decrease is continued for 24 hours. The amount of mTOR, 4E-BP1, and p70S6K proteins is slightly decreased.
In Vivo: BCH (200 mg/kg; intravenous injection; daily; for 14 days; male BALB/c nude mice) treatment significantly delays tumor growth and decreases glucose metabolism, indicating that LAT1 inhibition potentially suppresses esophageal cancer growth in vivo.
相关产品：Bioactive Compound Library Plus | Apoptosis Compound Library | Anti-Cancer Compound Library | Targeted Diversity Library | Human Metabolite Library | Highly Selective Activators Library | Cell Death Library | MG-132 | Doxorubicin hydrochloride | Bafilomycin A1 | LY294002 | Tamoxifen | Paclitaxel | Y-27632 | Acetylcysteine | Angiotensin II human | 2-Deoxy-D-glucose | Staurosporine | SB-431542 | Actinomycin D | Deferoxamine mesylate | Bortezomib | 5-Fluorouracil | Trametinib | Sorafenib | Oxaliplatin | Gemcitabine | Temozolomide | Rotenone | Mdivi-1 | Elesclomol | Ruxolitinib | Decitabine | SP600125 | MK-2206 dihydrochloride | Etoposide | Monomethyl auristatin E
热门产品线：重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物
Trending products：Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Dye Reagents | PROTAC | Isotope-Labeled Compounds
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验genome genetic and physical map data 78. IXDB http://ixdb.mpimg-berlin-dahlem.mpg.de/ Physical maps of human chromosome X 79. RHdb http://www.ebi.ac.uk/RHdb Radiation hybrid map data 80. The Unified Database http://bioinfo.weizmann.ac.il/udb
技术资料暂无技术资料 索取技术资料
