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- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
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MedChemExpress LLC
- CAS号：
445479-97-0
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg/50 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥2893.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥940.0 |
| 规格： | 5 mg | 产品价格： | ￥1880.0 |
| 规格： | 10 mg | 产品价格： | ￥2630.0 |
| 规格： | 25 mg | 产品价格： | ￥4476.0 |
| 规格： | 50 mg | 产品价格： | ￥5892.0 |
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BMS CCR2 22
CAS No. : 445479-97-0
MCE 国际站：BMS CCR2 22
产品活性：BMS CCR2 22 是一种有效的，特异性的和高亲和力的 CCR2 拮抗剂，对 CCR2 具有出色的结合亲和力 (IC50 为 5.1 nM)，并且具有强大的功能拮抗作用 (钙通量 IC50 为 18 nM，趋化性 IC50 为 1 nM)。
研究领域：GPCR/G Protein | Immunology/Inflammation
作用靶点：CCR
In Vitro: BMS CCR2 22 (Compound 22) has binding affinity for wild-type and E291A mutants with IC50 values of 7.5 nM and 3.7 nM, respectively.BMS CCR2 22 prevents both the binding and the internalization of fluorescently labeled hMCP-1_AF647 internalization in human monocytes. BMS CCR2 22 inhibits the internalization of hMCP1_AF647 with an IC50 value of approximately 2 nM.
The addition of BMS CCR2 22 (0.1-10 μM; 24 h), cenicriviroc (CVC) or a combination of both BMS CCR2 22 and MVC to human aortic endothelial cells (HAoECs) prior to MCP-1 stimulation do not alter E-selectin, ICAM-1, or CD99 cell surface expression. Incubation of HAoECs with BMS CCR2 22 before MCP-1 significantly increases VCAM-1 and PECAM1 cell surface levels (from 72.8 to 160% and from 97.2 and 127%, respectively).
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文献和实验, C20orf97, CTMP, GNB1, GRB2, GRB10, HSPB1, HSPCA, HSPCB, ILK, IMPDH1, INPP5D, INPPL1, MTCP1, PDK2, PDPK1, PIK3CA, PIK3CB, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R4, PPP2R5A, PPP2R5B, PPP
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