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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years. In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
KAR5585
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- 规格：
1 mg/5 mg
| 规格： | 1 mg | 产品价格： | ￥3680.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥9200.0 |
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Rodatristat ethyl
CAS No. : 1673571-51-1
MCE 国际站：Rodatristat ethyl
产品活性：Rodatristat ethyl (KAR5585) 是一种首创的,具有口服活性的 tryptophan hydroxylase 1 (TPH1) 抑制剂，具有体外纳摩尔浓度，可降低 5-hydroxytryptamine (5-HT) 的水平并显着降低肺动脉高压 (PAH)，
研究领域：Metabolic Enzyme/Protease | GPCR/G Protein | Neuronal Signaling
作用靶点：Tryptophan Hydroxylase | 5-HT Receptor
In Vivo: Rodatristat ethyl (100 or 200 mg/kg; oral administration; once daily; for 28 days; male Sprague-Dawley rats) treatment decreases erum, gut and lung 5-HT levels in a dose-dependent manner and significantly reduces pulmonary arterial pressure, and pulmonary vessel wall thickness and occlusion in male rats with monocrotaline (MCT).
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文献和实验Phycoerythrin conjugation protocol
(Molecular Probes) DTT Dithiothreitol NEM N-ethyl maleimide * 10 ml Sephadex G-10 columns (2) Separation column A long Sephacryl S-300 column
Quantitation of Acetaldehyde-DNA Adducts: Biomarkers of Alcohol Consumption
-tandem mass spectrometry-selected reaction monitoring (LC-ESI-MS/MS-SRM) method for the analysis of N2-Ethylidene-dGuo as its reduced form N 2 -ethyl-dGuo has been developed. This assay is based on addition of the reducing agent NaBH3 CN to the DNA
30-50 μm fixed frozen/vibratome sections, mounted on slides Beakers to mix and hold solutions Incubation chamber Solutions Cresyl fast violet Glacial acetic acid 100% ethyl alcohol Chloroform 95% ethyl alcohol / 5% deionized H2
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