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JNJ-10198409
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Powder: -20°C, 3 years. In solvent: -80°C, 6 months; -20°C, 1 month.
货期:1-2天
MedChemExpress LLC
10 mM * 1 mL/1 mg/5 mg
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CAS No. : 627518-40-5
MCE 国际站:JNJ-10198409
产品活性:JNJ-10198409 是一种相对选择性的,具有口服活性的,ATP 竞争性的血小板衍生生长因子受体酪氨酸激酶 (PDGF-RTK) 抑制剂 (IC50=2 nM)。它是一种双重机制的抗血管生成和肿瘤细胞的抗增殖剂。JNJ-10198409 对 PDGFR-β 激酶 (IC50=4.2 nM) 和 PDGFR-α 激酶 (IC50=45 nM) 有较好的抑制作用。
研究领域:Protein Tyrosine Kinase/RTK
作用靶点:PDGFR
In Vitro: JNJ-10198409 has potent antiproliferative activity in six of eight human tumor cell lines (IC50<0.033 μM) and is a potent inhibitor of the c-Abl kinase (IC50=22 nM).
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