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Recombinant Human SP-D/Pulmon

ary surfactant-associated protein D
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  • 询价
  • 上海谷研
  • GOY-9757
  • 进口、国产
  • 2025年07月16日
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      上海谷研

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      39

    • 规格

      10ug

    公司供应的产品仅用于科研
    产品名称: Recombinant Human SP-D/Pulmonary surfactant-associated protein D
    Known as    Pulmonary Surfactant-Associated Protein D; PSP-D; SP-D; Collectin-7; Lung Surfactant Protein D; SFTPD; COLEC7; PSPD; SFTP4
    Derived from    Human cells
    Purity    Greater than 95% as determined by reducing SDS-PAGE.
    Formulation    Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.
    Shipping    The product is shipped at ambient temperature.
    Storage    Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7°C for 2-7 days.Aliquots of reconstituted samples are stable at < -20°C for 3 months
    Reconstitution    Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
    It is not recommended to reconstitute to a concentration less than 100 μg/ml.
    Dissolve the lyophilized protein in ddH2O.
    Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
    Endotoxin    Less than 0.1 ng/ug (1 IEU/ug) as determined by LAL test.
    Background    Surfactant Pulmonary-Associated Protein D (SP-D) is a 43 kDa member of the collectin family of innate immune modulators. Its principal components consist of a collagen-like region and a C-terminal carbohydrate recognition domain (CRD), a structure that places it in a subset of pattern recognition proteins termed defense collagens. SP-D is constitutively secreted by alveolar lining cells and epithelium associated with tubular structures and induced in cardiac smooth muscle and endothelial cells. It binds both secreted and transmembrane proteins that transduce its function. It binds human neutrophil defensins, modulating influenza anti-viral defense. It binds MD-2/LY96, a secreted protein that cooperates with Toll-like receptors (TLRs) in the response of macrophages to bacterial lipopolysaccharides (LPS) or cell wall components. It also binds macrophage CD14 and TLRs directly, blocking binding of LPS and down-regulating TNF-α secretion. SP-D binding of both SIRPα and the calreticulin/CD91 complex on macrophages allows for a graded response to environmental challenge.
    Recombinant Human Pulmonary Surfactant-Associated Protein D is produced by our Mammalian expression system and the target gene encoding Ala21-Phe375(Glu22Gly)? is expressed with a 6His tag at the C-terminus.
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