- 询价
- Cell Signaling Technology
- 3664
- USA
- 2025年12月17日
- W
- H,Mk
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- 详细信息
- 询价记录
- 技术资料
- 抗体英文名：
RhoE (4) Mouse mAb
- 抗原：
full length recombinant human RhoE
- 应用范围：
W
- 供应商：
CST
- 保质期：
详见说明书
- 适应物种：
H,Mk
- 级别：
详见MSDS文件
- 库存：
大量
- 是否单克隆：
1
- 保存条件：
-20°c
- 规格：
100 ul (10 western blots)/carrier free & custom formulation / quantity
| 规格： | 产品价格： | ￥请询价 | |
|---|---|---|---|
| 规格： | 100 ul (10 western blots) | 产品价格： | ￥请询价 |
| 规格： | carrier free & custom formulation / quantity | 产品价格： | ￥请询价 |
pathway more info application references datasheet PDF MSDS PDF protocols
Applications Key: W=Western Blotting
Reactivity Key: H=Human Mk=Monkey
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.
| Applications | Reactivity | Sensitivity | MW (kDa) | Isotype |
|---|---|---|---|---|
| W | H Mk | Endogenous | 29 | Mouse IgG1 |
| Protocols |
|
|---|---|
| Specificity / Sensitivity | RhoE (4) Mouse mAb detects endogenous levels of total RhoE protein. |
| Source / Purification | Monoclonal antibody is produced by immunizing animals with full length recombinant human RhoE. Western Blotting
Western blot analysis of extracts from various cell types using RhoE (4) Mouse mAb. |
| Background | Rho family small GTPases act as molecular switches that regulate processes such as cell migration, adhesion, proliferation and differentiation. Typically, they are activated by guanine nucleotide exchange factors (GEFs), which catalyze the exchange of bound GDP for GTP, and are inhibited by GTPase activating proteins (GAPs), which catalyze the hydrolysis of GTP to GDP (1). Rnd1, Rnd2 and RhoE/Rnd3 comprise the evolutionarily divergent Rnd family of Rho-type small GTPases, which lack GTPase activity and therefore remain in a GTP-bound state (2, reviewed in 3). RhoE/Rnd3 activity leads to a decrease in stress fibers and increased cell migration, at least in part through regulation of the Rho-dependent kinase ROCK1 (4). Activity of RhoE/Rnd3 itself is regulated by ROCK1, which phosphorylates RhoE/Rnd3 at Ser11, enhancing its activity (5). RhoE/Rnd3 has been implicated in inhibition of DNA-damage induced apoptosis (6) and cell cycle arrest (7). In keratinocytes, RhoE/Rnd3 regulates differentiation through its effects on both proliferation and adhesion (8).
|
| Application References | Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know ! |
| Companion Products |
For Research Use Only. Not For Use In Diagnostic Procedures. |
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