- 询价
- Cell Signaling Technology
- 4683
- USA
- 2025年10月27日
- W
- Rabbit
- H
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- 详细信息
- 技术资料
- 抗体英文名：
DKK2 (G44) Antibody
- 抗原：
synthetic peptide corresponding to residues surrounding Gly44 of human DKK2
- 应用范围：
W
- 宿主：
Rabbit
- 适应物种：
H
- 级别：
详见MSDS文件
- 供应商：
CST
- 库存：
大量
- 保质期：
详见说明书
- 是否单克隆：
2
- 保存条件：
-20°c
- 规格：
100 ul (10 western blots)/carrier free & custom formulation / quantity
| 规格： | 产品价格： | ￥请询价 | |
|---|---|---|---|
| 规格： | 100 ul (10 western blots) | 产品价格： | ￥请询价 |
| 规格： | carrier free & custom formulation / quantity | 产品价格： | ￥请询价 |
pathway more info application references datasheet PDF MSDS PDF protocols
Applications Key: W=Western Blotting
Reactivity Key: H=Human
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.
| Applications | Reactivity | Sensitivity | MW (kDa) | Source |
|---|---|---|---|---|
| W | H | Transfected Only | 28, 32 | Rabbit |
| Protocols |
|
|---|---|
| Specificity / Sensitivity | DKK2 (G44) Antibody detects transfected levels of human DKK2 protein. This antibody does not cross-react with DKK1. |
| Source / Purification | Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly44 of human DKK2. Antibodies are purified by peptide affinity chromatography. Western Blotting
Western blot analysis of extracts from COS cells, untransfected or transiently transfected with a construct expressing DKK2, using DKK2 (G44) Antibody. |
| Background | Dickkopf (DKK) family proteins consist of four members DKK1, DKK2, DKK3 and DKK4 that function as secreted Wnt antagonists by inhibiting Wnt coreceptors LRP5 and LRP6 (1,2). DKKs contain two cysteine-rich domains in which the positions of 10 cysteine residues are well conserved (3). Their expression is both temporally and spatially regulated during animal development (4). DKKs also bind with high affinity to transmembrane proteins Kremen1 and 2, which themselves also modulate Wnt signaling (5,6). DKK2 plays a role in osteoblast terminal differentiation and formation of mineralized matrix and is required for differentiation of non-keratinizing stratified epithelium from the corneal epithelial progenitors (7,8).
|
| Application References | Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know ! |
| Companion Products |
For Research Use Only. Not For Use In Diagnostic Procedures. |
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