- 询价
- Cell Signaling Technology
- 5383
- USA
- 2025年10月15日
- W, IP
- Rabbit
- H,M,R,Mk
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- 详细信息
- 询价记录
- 文献和实验
- 技术资料
- 抗体英文名：
Phospho-Tau (Thr181) Antibody
- 抗原：
synthetic phosphopeptide corresponding to residues surrounding Thr181 of human Tau protein
- 应用范围：
W, IP
- 宿主：
Rabbit
- 供应商：
CST
- 适应物种：
H,M,R,Mk
- 级别：
详见MSDS文件
- 保质期：
详见说明书
- 库存：
大量
- 是否单克隆：
2
- 保存条件：
-20°c
- 规格：
100 ul (10 western blots)/carrier free & custom formulation / quantity
| 规格： | 产品价格： | ￥请询价 | |
|---|---|---|---|
| 规格： | 100 ul (10 western blots) | 产品价格： | ￥请询价 |
| 规格： | carrier free & custom formulation / quantity | 产品价格： | ￥请询价 |
pathway more info application references datasheet PDF MSDS PDF protocols
Applications Key: W=Western Blotting IP=Immunoprecipitation
Reactivity Key: H=Human M=Mouse R=Rat Mk=Monkey
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.
| Applications | Reactivity | Sensitivity | MW (kDa) | Source |
|---|---|---|---|---|
| W IP | H M R (Mk) | Endogenous | 50-80 | Rabbit |
| Protocols |
|
|---|---|
| Specificity / Sensitivity | Phospho-Tau (Thr181) Antibody recognizes endogenous levels of Tau protein only when phosphorylated at Thr181. |
| Source / Purification | Polyclonal antibodies are produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Thr181 of human Tau protein. Antibodies are purified by protein A and peptide affinity chromatography. Western Blotting
Western blot analysis of extracts from mouse and rat brain using Tau (Tau46) Mouse mAb #4019 (red) and Phospho-Tau (Thr181) Antibody (green). The phospho-specificity of Phospho-Tau (Thr181) Antibody was verified by peptide blocking using a phosphopeptide or non-phosphopeptide. Western blot image was obtained using the Odyssey® Infrared Imaging System (LI-COR® Biotechnology). Western Blotting
Western blot analysis of extracts from mouse and rat brain using Phospho-Tau (Thr181) Antibody. |
| Background | Tau is a heterogeneous microtubule-associated protein that promotes and stabilizes microtubule assembly, especially in axons. Six isoforms with different amino-terminal inserts and different numbers of tandem repeats near the carboxy-terminus have been identified, and tau is hyperphosphorylated at approximately 25 sites by Erk, GSK-3, and CDK5 (1,2). Phosphorylation decreases the ability of tau to bind to microtubules. Neurofibrillary tangles are a major hallmark of Alzheimer's disease; these tangles are bundles of paired helical filaments composed of hyperphosphorylated tau. In particular, phosphorylation at Ser396 by GSK-3 or CDK5 destabilizes microtubules in Alzheimer's disease. Furthermore, inclusions of tau are found in a number of other neurodegenerative diseases, collectively known as tauopathies (1,3). The cerebrospinal fluid concentration of Tau phosphorylated at Thr181 has been proposed to be a biomarker for the study of neurodegenerative disorders (4). |
| Application References | Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know ! |
| Companion Products |
For Research Use Only. Not For Use In Diagnostic Procedures. |
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- 作者
- 内容
- 询问日期
文献和实验Using Phospho‐Motif Antibodies to Determine Kinase Substrates
comprising both the phosphorylated residue and the surrounding residues that determine kinase specificity, with degenerate residues taking up the remaining positions. Currently, several categories of phospho?motif antibody are commercially available
上海西唐生物科技有限公司 021-55229872, 65333639 www.westang.com 人TAU 蛋白 (TAU)ELISA 试剂盒 ( 用于血清、血浆、细胞培养上清液和其它生物体液内 ) 原理 本实验采用双抗体夹心 ABC-ELISA 法。用抗人 TAU 单抗包被于酶标板上，标准品和样品中的 TAU与单抗结合，加入生物素化的抗人 TAU ，形成免疫复合
上海西唐生物科技有限公司 021-55229872, 65333639 www.westang.com 大鼠 Tau 蛋白 (Tau)ELISA 试剂盒 ( 用于血清、血浆、细胞培养上清液和其它生物体液内 ) 原理 本实验采用双抗体夹心 ABC-ELISA 法。用抗大鼠 Tau 单抗包被于酶标板上，标准品和样品中的 Tau 与单抗结合，加入生物素化的抗大鼠 Tau ，形成免疫复合物连接在板上，辣根
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