- 询价
- Cell Signaling Technology
- 3816
- USA
- 2025年10月05日
- W, IP
- M,R,H
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- 详细信息
- 技术资料
- 抗体英文名：
Plexin A4 (C5D1) Rabbit mAb
- 抗原：
GST-fusion protein corresponding to residues from the human sequence of Plexin A4
- 应用范围：
W, IP
- 保质期：
详见说明书
- 库存：
大量
- 级别：
详见MSDS文件
- 供应商：
CST
- 适应物种：
M,R,H
- 是否单克隆：
1
- 保存条件：
-20°c
- 规格：
100 ul (10 western blots)/carrier free & custom formulation / quantity
| 规格： | 产品价格： | ￥请询价 | |
|---|---|---|---|
| 规格： | 100 ul (10 western blots) | 产品价格： | ￥请询价 |
| 规格： | carrier free & custom formulation / quantity | 产品价格： | ￥请询价 |
pathway more info application references datasheet PDF MSDS PDF protocols
Applications Key: W=Western Blotting IP=Immunoprecipitation
Reactivity Key: H=Human M=Mouse R=Rat
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.
| Applications | Reactivity | Sensitivity | MW (kDa) | Isotype |
|---|---|---|---|---|
| W IP | M R (H) | Endogenous | 212 | Rabbit IgG |
| Protocols |
|
|---|---|
| Specificity / Sensitivity | Plexin A4 (C5D1) Rabbit mAb detects endogenous levels of total Plexin A4 protein. |
| Source / Purification | Monoclonal antibody is produced by immunizing animals with a GST-fusion protein corresponding to residues from the human sequence of Plexin A4. Western Blotting
Western blot analysis of extracts from mouse brain and rat brain using Plexin A4 (C5D1) Rabbit mAb. |
| Background | Class 3 secreted semaphorin (Sema3A) is a chemorepellent that acts upon a wide variety of axons. As such, it induces a dramatic redistribution and depolymerization of actin filaments that results in growth cone collapse. Plexins are single membrane-spanning signaling proteins encompassing Plexin A1, A2, A3, and A4. Plexins form a complex with neuropilin-1 and -2 and the cell adhesion protein L1 to form a functional semaphorin receptor (1,2). The GTPase Rnd1 binds to the cytoplasmic domain of Plexin A1 to trigger cytoskeletal collapse. In contrast, the GTPase RhoD blocks Rnd1-mediated Plexin A1 activation and repulsion of sympathetic axons by Sema3A (3). Both Plexin A3 and A4 mediate the responses to class 3 Semaphorins in sensory and sympathetic neurons. In particular, Plexin A4 is responsible for signaling of Sema3A via neuropilin-1, while Plexin A3 is responsible for signaling of Sema3F via neuropilin-2 (4). |
| Application References | Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know ! |
| Companion Products |
For Research Use Only. Not For Use In Diagnostic Procedures. |
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