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- 2026年02月08日
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- 详细信息
- 文献和实验
- 技术资料
- 库存：
100
- 国食药监械注册号：
无
- 保修期：
12个月
- 现货状态：
10天
- 供应商：
玉研仪器公司
- 规格：
敬请来电咨询
The MicroSprayer® Aerosolizer – Model IA-1C operates with our FMJ-250 High-Pressure Syringe to generate a plume of soft mist directly into the lungs without any propellant or compressed air. Available in any length, and made entirely of sterilizable components, the Model IA-1C MicroSprayer® Aerosolizer can be inserted deep into the trachea up to the carina, or even in selected secondary airways of larger species. It produces a much deeper and more uniform distribution than is possible with liquid bolus or droplet instillation,while permitting greater concentration, quantifiability and control than is possible with inhaler/nebulizer delivery. Aerosol is generated by a unique, patented atomizer at the very tip of the device. Standard sizes are available for mouse that measure (1 1/4”) or rat (2”) after a 120- degree bend. Custom sizes and configurations on request for nasal sprayers, straight tubes, or longer lengths for guinea pig, rabbit, dog, monkey, horse or other larger species.
Model IA-1C Specifications
• Based on 23-gauge stainless steel, thin-wall needle tubing with an outer diameter (o.d.) of .025”
(.64 millimeters), except at the very tip which is .028” and an inner diameter (i.d.) of .017”
• Fully sterilizable, autoclavable, stainless steel and chemically-resistant internal components
• 1/4-28 tpi threaded female hub
• Available in any length or configuration (straight or with standard 120-degree bend)
• Suitable for insertion into an endotracheal tube or the working channel of a bronchoscope
FMJ-250 High Pressure Syringe Specifications
• Required for use with our Model IA-1C MicroSprayer® Aerosolizer
• Constructed of stainless steel and chemically-resistant components with a replaceable plunger with a
Teflon® tip
• Fully sterilizable and autoclavable at standard temperatures
• Operates at 3000 psi
• Capacity: 250 μl. A set of clips is provided with each syringe to permit precise dosing of 25 or 50 μl, or
combinations of those amounts
Particle size: When analyzed with laser defraction, the Model IA-1C produced a particle size distribution with a
Mass Median Diameter (MMD) of 16-22 μm – when used with our special FMJ-250 High Pressure Syringe (sold
separately). Results may vary, depending upon method of particle size analysis used, material delivered and
sprayer tip length.
MicroSprayer Aerosolizers
Dry Powder Insufflator
Selection Guide:
For precise intratracheal aerosol doses up to 1ml in Rat, Guinea Pig, or other animals or uses
| MicroSprayer Aerosolizer= | Spray-Head+ | Syringe |
| IA-1B-R Rat | IA-1B-R Rat(2″ tip) | 1ml: B-SYR-PL1000 0.5ml: B-SYR-GL500 |
| IA-1B-GP Guinea Pig | IA-1B-GP Guinea Pig(3″ tip) | |
| IA-1B-C Customize length | IA-1B-C Customize length |
For precise intratracheal aerosol doses of 25-μl to 250-μl in Mouse, Rat, or other animals or uses
| MicroSprayer Aerosolizer= | Spray-Head+ | Syringe |
| MSA-250-M Mouse | IA-1C-M Mouse(1.25″ tip) | FMJ - 250 Dosage:25—250 μl |
| MSA-250-R Rat | IA-1C-R Rat(2″ tip) | |
| MSA-250-C Customize length | IA-1C-C Customize length |
For precise intratracheal dry powder doses of 1 to 5mg in Rat, Guinea Pig, or other animals or uses
| Dry Powder Insufflator= | Spray-Head+ | Syringe |
| DP- 4-R Rat | DP- 4-R Rat(2″ tip) | 3ML Syringe or Optional AP-1 PUMP |
| DP- 4-GP Guinea Pig | DP- 4-GP Guinea Pig(3″ tip) | |
| IA-1B-C Customize length |
For precise intratracheal dry powder doses of 1 to 2mg in Mouse only
| Dry Powder Insufflator Air Pump Assembly= | Spray-Head+ | Pump |
| DPM- APA | DP- 4M | AP-1 PUMP |
USE GUIDE
The process of intratracheal administration is essentially a form of intubation. For intrapulmonary applications, the tip of the device is gently inserted down the trachea of the anesthetized animal – near to, but not touching the carina (first bifurcation).
CONTACT INFORMATION
Shanghai Yuyan Instruments Co, Ltd.
Address: Room 506, XingMei Rd 485, Shanghai, 201100, China
小动物肺部液体雾化给药器 YAN-30012型
玉研仪器公司专业研制十三年，权威报告实现精细化粒径范围，定量有效到达肺部提高药量精性，减少药物浪费。支持气溶胶或干粉药物，高分文献数量多。
· 定量 QUANTIFIABLE：将定量的气溶胶给到动物肺部
· 定时 TIMED：可以在一个或多个时间点进行给药
· 有效 EFFECTIVE：气溶胶的吸收效果好，给药快速，效率高，操作方便
· 方便 CONVENIENCE：维护简单，操作方便
详细介绍
专业研制十三年，权威报告实现精细化粒径范围，定量有效到达肺部提高药量精性，减少药物浪费。支持气溶胶或干粉药物，高分文献量多。肺部液体雾化给药器是上海玉研仪器专门为小鼠、大鼠、豚鼠等小动物研发设计，可精确进行气管内雾化给药的装置。可将定量液体通过集成在不锈钢毛细插管中的气溶胶雾化微喷头雾化，毛细插管可深入动物至支气管分叉处，实现气管内定量雾化成气溶胶给药。相较于传统口服或注射给药，药物可直接作用于肺部，适用于肺部生理、病理、药理学研究。
优势特点
1、适用于小鼠、大鼠、豚鼠、兔子等小动物，也可定制大动物专用款3、微量精确给药，最小药物用量25μL（液体）
4、可用于溶液、小细胞悬浮液、均质悬浊液、粘度较低的乳浊液、干粉等给药
5、90%药物雾化直径≤30μm（液体），可达终末细支气管甚至呼吸性细支气管，可均匀分布于大小鼠肺部组织中
6、使用方便，安全稳定，采用不锈钢材质，坚固稳定耐腐蚀
7、具有至少30篇高影响因子SCI文献发表，可提供至少1篇IF大于35分的SCI文献
8、设备具有CE认证证书或EC符合性证书
9、可用于吸入毒理学、空气生物学、生物危害测试、吸入免疫、吸入治疗、药物研究、环境评价、危害评估和医学防护等多领域
应用领域
1、研究肺部吸收机制：通过给予标记的药物,可以观察药物在肺泡和肺间质中的吸收和转运过程，也可以准确测定药物在肺泡、肺间质等不同部位的吸收速率和吸收程度，从而建立可靠的药物吸收模型。
2、分析肺部代谢过程 :使用肺部给药技术,可以检测给药后药物在肺内代谢产物的形成和变化，帮助分析肺部代谢酶的活性和代谢途径，也可以分析药物在肺内的代谢动力学，包括代谢速率、代谢产物的形成和清除。
3、评估肺部清除机制：肺部给药可作用于肺部，研究肺泡巨噬细胞、肺表面活性物质、纤毛运动等对药物清除的影响。
4、探索肺部免疫反应和屏障功能：通过肺部给予免疫刺激药物，可以观察肺部免疫细胞的激活和炎症反应。使用标记的粒子或大分子作为探针，可以评估肺血管内皮、上皮等屏障结构对物质通透性的调控作用。
5、建立肺部-全身循环的药动学模型：通过肺部给药数据，可以建立详细的肺部-血浆-全身循环的药动学模型，更准确地预测药物在体内的吸收、分布、代谢和清除过程。
气管内给药示意图
肺纤维化大小鼠模型
传统经典的复制肺纤维化大小鼠模型方法是通过气管内滴入博莱霉素溶液，其主要方式有两种：有创气管切开滴注以及无创经口气管滴注。有创气管切开滴注会对实验动物造成外源性损伤，增加了实验动物失血过多和感染的风险，无创经口气管滴注可引起明显的肺组织损伤与肺纤维化改变，但溶液呈液滴状进入肺内，其液滴相对较大，药物较集中，容易造成动物窒息死亡。
无创经口气管内雾化给药则是一种更新、更有效的促进药物肺内均匀分布的给药方法，可以将博莱霉素溶液分散为体积更小的液滴，在气流的推动下，分散的液滴能进入各肺叶，并可到达外周肺组织，因此造成累及各肺叶、出现程度相近的纤维化改变、范围更弥散的肺组织损伤，更接近人类肺纤维化改变。气管内雾化博莱霉素溶液对小鼠的创伤小，很少出现窒息的情况，且不需穿刺气管，减少了动物的损伤与痛苦，降低了实验鼠的死亡率，并且药物剂量可以准确控制，实验结果重复性好，可作为复制肺纤维化大小鼠模型的优选方案。
由于大小鼠肺部疾病模型造模指向性强，需要直接将造模药物均匀输送到肺组织中。因此包括哮喘模型，肺纤维化模型，急性肺组织损伤模型，病毒感染模型等肺部疾病模型均可使用经口气管内雾化给药造模。
相关产品推荐：
合适的工具能帮助您更好地完成工作，气管插管台和小动物喉镜是帮助您完成肺部给药手术的得力助手，推荐与肺部干粉雾化给药器配合使用。
气管插管平台
气管插管平台支持小鼠、大鼠等小动物在一个稳定舒适的体位进行气管插管、药物灌注及其它类似实验操作。可以根据需要进行不同孔位的固定，进行多种操作角度的调节，满足不同实验类型以及实验动物种类的需求。双面操作模式，使得肺部给药操作更为流畅顺利，可与我公司小动物呼吸机、麻醉机、肺部定量给药器、喉镜等配合使用，也可根据要求进行定制。
CG-02型
| 适用 | 尺寸 |
| 小鼠 | 20×15×20cm |
| 大鼠 | 22×21×28cm |
CG-04型
| 适用 | 尺寸 |
| 小鼠 | 20×15×20cm |
| 大鼠 | 20×15×20cm |
CG-06型
| 适用 | 尺寸 |
| 小鼠 | 15×12×15cm |
| 大鼠 | 30×20×20cm |
小动物喉镜
SR310型小动物喉镜，用于观察实验动物的喉部等结构，以进行肺部给药、经口气管插管等操作，适用于小鼠、大鼠、豚鼠，也可根据您的要求进行定制。采用光纤LED照明系统，提供清晰明亮的光线，给观察喉部、会厌等结构的操作人员提供了更好的视野。前端为不锈钢的叶型尖端，可随时拆卸或更换。操作柄的形状符合人体工程学，使操作更舒适方便。
产品特点：
1.外壳采用金属材质，坚固耐用，易清洗
2.操作柄的形状符合人体工程学的原理，手握舒适
3.专为大小鼠口腔结构设计的特制叶片，解决了因口腔太小难以进行气管插管的难题
4.具有大鼠叶片和小鼠叶片供选择
5.叶片采用不锈钢材质，最大限度地减少腐蚀，确保耐用
6.电池采用两节5号电池，方便更换
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文献和实验参考文献：
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5.Fan, Weiyang et al. “Naringenin regulates cigarette smoke extract-induced extracellular vesicles from alveolar macrophage to attenuate the mouse lung epithelial ferroptosis through activating EV miR-23a-3p/ACSL4 axis.” Phytomedicine : international journal of phytotherapy and phytopharmacology vol. 124 (2024): 155256. doi:10.1016/j.phymed.2023.155256
6.Li, Cheng et al. “Broad neutralization of SARS-CoV-2 variants by an inhalable bispecific single-domain antibody.” Cell vol. 185,8 (2022): 1389-1401.e18. doi:10.1016/j.cell.2022.03.009
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10.Santin, Yohan et al. “Inhalation of acidic nanoparticles prevents doxorubicin cardiotoxicity through improvement of lysosomal function.” Theranostics vol. 13,15 5435-5451. 2 Oct. 2023, doi:10.7150/thno.86310
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12.Yue, Dayong et al. “Diesel exhaust PM2.5 greatly deteriorates fibrosis process in pre-existing pulmonary fibrosis via ferroptosis.” Environment international vol. 171 (2023): 107706. doi:10.1016/j.envint.2022.107706
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技术资料
