CD4 is a member of the immunoglobulin superfamily and is implicated as associative recognition element in MHC (Major Histocompatibility Complex) class II-restricted immune response. On T-lymphocytes, it defines the helper/inducer subset. The mature 55 kd CD4 protein consists of a 372 amino acid extracellular segment composed of four tandem immunoglobulin-like VJ regions. The CD4 molecule is a major receptor for human immunodeficiency virus (HIV), binding directly to the envelope glycoprotein gp120 on HIV, with the co-receptors being CCR5 or CXCR4. It has been shown that the V-like domains are critical for binding with HIV envelope gp120.
克隆类型:
Mouse Monoclonal Antibody
亚型:
Mouse IgG1
免疫原:
193-aa recombinant protein within the N-term region of human CD4.
适用物种:
H, M, R
应用范围:
E, WB
应用说明:
E: 1:500-1:1,000; WB: 1:100-1:500
别名:
CD4; CD4 antigen; CD4 receptor
形态:
Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.02% sodium azide. Antibody was purified by Protein-A affinity chromatography.
保存条件:
Store at 4°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.