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- 详细信息
- 文献和实验
- 技术资料
- 免疫原:
Purified recombinant fragment of PARL(aa112-167) expressed in E. coli. <br>
- 亚型:
Mouse IgG2b
- 形态:
Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
- 保存条件:
Store at -20°C
- 克隆性:
单克隆
- 标记物:
见下方详细说明
- 适应物种:
H
- 保质期:
1-2年
- 抗原来源:
Purified recombinant fragment of PARL(aa112-167) expressed in E. coli. <br>
- 目录编号:
252797
- 级别:
超纯
- 库存:
大量
- 供应商:
Abbiotec
- 宿主:
Mouse
- 应用范围:
WB
- 浓度:
见详细说明信息
- 靶点:
PARL (8C4B)
- 抗体英文名:
PARL (8C4B) Antibody
- 抗体名:
PARL (8C4B) Antibody
- 规格:
0.1 ml
PARL (8C4B) Antibody产品详细介绍:
| 产品名称: | PARL (8C4B) Antibody |
| 说明书: | 【点击查看详细说明及参考图片】 |
| 货号: | 252797 |
| 规格: | 0.1 ml |
| 产品描述: | PARL (Presenilin Associated Rhomboid-Like protein) is a mitochondrial integral membrane protein. Following proteolytic processing of this protein, a small peptide (P-beta) is formed and translocated to the nucleus. This protein may be involved in signal transduction via regulated intramembrane proteolysis of membrane-tethered precursor proteins. Variation in this protein has been associated with increased risk for type 2 diabetes. |
| 克隆类型: | Mouse Monoclonal Antibody |
| 亚型: | Mouse IgG2b |
| 免疫原: | Purified recombinant fragment of PARL(aa112-167) expressed in E. coli. |
| 适用物种: | H |
| 应用范围: | WB |
| 应用说明: | WB: 1:500-1:2000; |
| 别名: | Presenilins-associated rhomboid-like protein, mitochondrial; Mitochondrial intramembrane cleaving protease; PARL; Pbeta; PSARL; PARL |
| 形态: | Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide. |
| 保存条件: | Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment. |
| 参考文献: |
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文献和实验补体成分 C4(C4a/C4b) 补体成分:C4 血清浓度(μg/ml):200~500 分子量(kDa):210 亚单位(链)及分子量(kDa):α:90β:78γ:33 激活产物:C4a;C4b 生物学活性:C4a 弱的过敏毒素作用 C4b 组成CP中的C3、C5转化
Evaluation of Complement-Dependent Cytotoxicity Using ATP Measurement and C1q/C4b Binding
method to evaluate the binding of C1q on the Fc region and the binding of C4b on cell surface. The luminescence method coupled with complement protein analysis by flow cytometry encompasses all needed methods to evaluate antibody ability to trigger CDC.
4、IgA、IgD和IgE不能结合补体。电镜下观察发现,C1q的球形结构与抗体结合后,医学教|育网搜集整理进一步激活C1r和C1s,C1s具有酯酶活性,继之进入下一步的连续反应。研究还发现激活C1q的球形分子必须具有2个以上紧密相邻的IgG分子,IgM只需1分子即可,故单分子IgM比IgG激活补体的能力大得多,在补体介导的抗体溶细胞反应中,同量的IgM比IgG更有效。 2.活化阶段此阶段主要形成2种重要的转化酶:C3转化酶C4b3b和C5转化酶C4b2b3b.C4和C2均为C1酯酶的天然底物,C1
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