- ￥3000 - 3999
- Abbiotec
- 美国
- 252710
- 2025年07月13日
- E, WB, IHC
- Mouse
- H
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
Purified recombinant fragment of P16 expressed in E. coli.
- 亚型：
Mouse IgG1
- 形态：
Each vial contains 0.1 mg IgG in PBS pH7.4 with 0.03% sodium azide. Antibody was purified by Protein-G affinity chromatography.
- 保存条件：
Store at -20°C
- 克隆性：
单克隆
- 标记物：
见下方详细说明
- 适应物种：
H
- 保质期：
1-2年
- 抗原来源：
Purified recombinant fragment of P16 expressed in E. coli.
- 目录编号：
252710
- 级别：
超纯
- 库存：
大量
- 供应商：
Abbiotec
- 宿主：
Mouse
- 应用范围：
E, WB, IHC
- 浓度：
见详细说明信息
- 靶点：
Human P16 (5A8A)
- 抗体英文名：
Human P16 (5A8A) Antibody
- 抗体名：
Human P16 (5A8A) Antibody
- 规格：
0.1 mg
Human P16 (5A8A) Antibody产品详细介绍：
| 产品名称： | Human P16 (5A8A) Antibody |
| 说明书： | 【点击查看详细说明及参考图片】 |
| 货号： | 252710 |
| 规格： | 0.1 mg |
| 产品描述： | CDK4I or p16-INK4 (Cyclin-dependent kinase 4 inhibitor A) is a negative regulator of the proliferation of normal cells. It is interacting strongly with CDK4 and CDK6 and by subsequently inhibiting their interaction with cyclins D and retinoblastoma protein phosphorylation. Defects in p16-INK4 are involved in tumor formation in a wide range of tissues. These defects cause cutaneous malignant melanoma 2 (CMM2), familial atypical multiple mole melanoma-pancreatic carcinoma syndrome, melanoma-astrocytoma syndrome and Li-Fraumeni syndrome. |
| 克隆类型： | Mouse Monoclonal Antibody |
| 亚型： | Mouse IgG1 |
| 免疫原： | Purified recombinant fragment of P16 expressed in E. coli. |
| 适用物种： | H |
| 应用范围： | E, WB, IHC |
| 应用说明： | E: 1:10000; WB: 1:500-1:2000; IHC: 1:200-1:1000 |
| 别名： | Human P16; P16; Cyclin-dependent kinase inhibitor 2A, isoforms 1/2/3; cyclin-dependent kinase inhibitor A; CDK4I; p16-INK4a; p16INK4A; p16-INK4; multiple tumor suppressor 1; MTS-1; CDKN2A; CDKN2; MTS1 |
| 形态： | Each vial contains 0.1 mg IgG in PBS pH7.4 with 0.03% sodium azide. Antibody was purified by Protein-G affinity chromatography. |
| 保存条件： | Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment. |
| 参考文献： |
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文献和实验Abrogation of the RB-p16Tumor Suppressor Pathway in Human Lung Cancer
There is compelling evidence that human lung cancers are characterized by disruption of several important physiological pathways that govern proliferation, apoptosis, intracellular signaling, and cell-cell interactions. Uncontrolled cellular
p16INK4A and Familial Melanoma
alterations affecting p16INK4A and cyclin D1 are so frequent in human cancers that inactivation of these proteins is believed to be necessary for tumor development. Broadly applicable anticancer therapies might be based on restoration of p16INK4A CDK
Analysis of p16INK4a and Integrated HPV Genomes as Progression Markers
Most cervical cancers are preventable when the precursor lesions are detected in time. Human papilloma viruses (HPVs) are the main risk factors for cervical cancer development, but there is a high percentage of healthy women infected with HPV
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