Chelerythrine

价格询价

品牌MedChemExpress(MCE)
产地美国
货号HY-N2359
更新日期2025年07月12日

MedChemExpress LLC

品牌商

14 年钻石会员

Chelerythrine

CAS No. : 34316-15-9

MCE 国际站：Chelerythrine

产品活性：Chelerythrine 是一种天然生物碱，为有效、选择性的 Ca²⁺/磷脂依赖性 PKC 拮抗剂，IC₅₀ 值为 0.7 μM。Chelerythrine 具有抗肿瘤、抗糖尿病、抗炎的活性。Chelerythrine 抑制 BclXL-Bak BH3 肽结合，IC₅₀ 为 1.5 μM，并从 BclXL 取代了 Bax。 Chelerythrine 诱导细胞凋亡和自噬。

研究领域：Epigenetics | TGF-beta/Smad | Apoptosis | Autophagy

作用靶点：PKC | Bcl-2 Family | Apoptosis | Autophagy

In Vitro: Chelerythrine (48 h) inhibits the growth of L-1210 cells (IC₅₀: 0.53 uM ).
Chelerythrine (0-20 μM, 24 h) inhibits cell viability, induces apoptosis and autophagy in A549 and NCI-H1299 cells.
Chelerythrine (0-5 μM, 24 or 48 h) induces apoptosis in BclXL-overexpressing SH-SY5Y cells.
Chelerythrine (2.5-10 μM, 16 h) induces mitochondrial depolarization (decrease in mitochondrial potential) in SH-SY5Y cells, and stimulates release of CytC from isolated mitochondria.
Chelerythrine (0-100 ng/mL, 24 h) reduces the LPS induced production of NO and TNF-α in primary macrophages.
Chelerythrine (MIC: 0.156 mg/mL) shows antibacterial activities against Gram-positive bacteria, Staphylococcus aureus (SA), MRSA, and extended spectrum β-lactamase S. aureus (ESBLs-SA).

In Vivo: Chelerythrine (5 mg/kg, i.p., daily) attenuates partial unilateral ureteral obstruction (UUO) induced kidney injury, and restores renal function in neonatal rats.
Chelerythrine (1-10 mg/kg, i.p., at 24 and 1 h before injection of 100 μg/kg LPS) shows anti-inflammatory effects (increased survival rate, decreased serum nitrite and TNF-α level) in LPS induced mice endotoxic shock model.