Paris saponin VII重楼皂苷 VII,6812

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Paris saponin VII

CAS No. : 68124-04-9

MCE 国际站：Paris saponin VII

产品活性：Paris saponin VII (Chonglou Saponin VII) 是从延龄草 (Trillium tschonoskii) 的根和根茎中分离的甾体皂苷。Paris saponin VII 诱导的 K562/ADR 细胞凋亡与 Akt/p38 MAPK 和 P-gp 的抑制有关。Paris saponin VII 减弱线粒体膜电位，增加凋亡相关蛋白 (Bax 和细胞色素 c) 的表达，并降低 Bcl-2，caspase-9，caspase-3，PARP-1 和 p-Akt 的蛋白表达水平。Paris saponin VII 在 K562/ADR 细胞中诱导强烈的自噬，可用于白血病的研究。

研究领域：PI3K/Akt/mTOR  |  MAPK/ERK Pathway  |  Membrane Transporter/Ion Channel  |  Apoptosis  |  Epigenetics  |  Cell Cycle/DNA Damage  |  Autophagy

作用靶点：Akt  |  p38 MAPK  |  P-glycoprotein  |  Bcl-2 Family  |  Caspase  |  PARP  |  Autophagy  |  Apoptosis

In Vitro: Paris saponin VII (Chonglou Saponin VII) inhibits the growth of adriamycin-resistant human leukemia cells (K562/ADR) in a dose-dependent manner. Paris saponin VII significantly suppresses cell proliferation by cell cycle arrest in the G0/G1 phase.

In Vivo: Paris saponin VII (Chonglou Saponin VII) (intravenous administration) significantly enhances anticancer efficacy of adriamycin to MCF-7/ADR xenograft model in nude mice.

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