Avicularin扁蓄苷,572-30-5

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Avicularin

CAS No. : 572-30-5

MCE 国际站：Avicularin

产品活性：Avicularin 是一种具有口服活性的黄酮类化合物。Avicularin 抑制 NF-κB (p65) , COX-2 和 PPAR-γ 的活性。Avicularin 具有抗炎、抗感染、抗过敏、抗氧化、保肝、抗肿瘤等作用。

研究领域：Immunology/Inflammation  |  NF-κB  |  Cell Cycle/DNA Damage  |  Vitamin D Related/Nuclear Receptor  |  Stem Cell/Wnt  |  MAPK/ERK Pathway  |  Membrane Transporter/Ion Channel  |  Apoptosis

作用靶点：COX  |  NF-κB  |  PPAR  |  ERK  |  GLUT  |  Apoptosis

In Vitro: Avicularin (10-300 μM, 1 h) suppresses NO and PGE₂ production in LPS-stimulated RAW 264.7 cells.
?Avicularin (10-300 μM, 1 h) exhibits anti-inflammatory activity through the suppression of ERK signaling pathway in LPS-stimulated RAW 264.7 cells.
?Avicularin (25-100 μg/mL, 48 h) decreases cell proliferation, cell migration and invasion in Huh7 cells.
?Avicularin (25-100 μg/mL, 48 h) induces apoptosis via the downregulation of NF?κB (p65) and COX?2 and the upregulation of PPAR?γ.
?Avicularin (50 μM, 6 days) decreases the intracellular lipids, along with decreased PPARγ, C/EBPα, and aP2 mRNA levels in 3T3-L1 cells.
?Avicularin (50 μM, 6 days) suppresses GLUT4-Mediated glucose uptake in 3T3-L1 cells.
?Avicularin (2.5-10 μM, 2 h) inhibits ECM degradation and inflammation via TRAF6/MAPK activation in rat and human chondrocytes.

In Vivo: Avicularin (injected in articular cavity of the knee, 0.5-2 mg/kg, twice a week for 4 weeks) attenuates the development of OA (osteoarthritis) in ACLT-induced rats.
?Avicularin (oral administration, 50 and 100 mg/kg, for 21 days) attenuates memory Impairment in rats with amyloid Beta-induced Alzheimer's disease.

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