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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
1419609-94-1
- 规格：
10 mM * 1 mL/1 mg/5 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥5633.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥2224.0 |
| 规格： | 5 mg | 产品价格： | ￥5560.0 |
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GSK2798745
CAS No. : 1419609-94-1
MCE 国际站：GSK2798745
产品活性：GSK2798745 是一种强效的、选择性的且具有口服活性的瞬时受体电位香草酸 4 (TRPV4) 离子通道阻断剂，对 hTRPV4 和 rTRPV4 的 IC50 值分别为 1.8 和 1.6 nM。GSK2798745 可用于心脏和呼吸系统疾病研究。
研究领域：Membrane Transporter/Ion Channel | Neuronal Signaling
作用靶点：TRP Channel
In Vitro: GSK2798745 inhibits TRPV4 agonist-induced impedance reduction in human umbilical vein endothelial cells (HUVECs).
In Vivo: GSK2798745 inhibits TRPV4 agonist-mediated lung edema in rats in a dose-dependent manner.
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v468. chapter 4 WNT 细胞通路 检测细胞GSK3活性与表达水平
Measuring GSK3 Expression and Activity in Cells Methods in Molecular Biology v468. chapter 4 Abstract Glycogen synthase kinase (GSK)-3 is a key signalling intermediate in the action of Wnts. This protein kinaseis ubiquitously expressed
Wnt/β-catenin信号通路在实验性大鼠肝癌形成过程中的作用
Wnt /β-catenin信号转导通路是一条在生物进化中极为保守的通路。在正常的体细胞中，β-catenin只是作为一种细胞骨架蛋白在胞膜处与E-cadherin形成复合体对维持同型细胞的黏附、防止细胞的移动发挥作用。只有当细胞外Wnt信号分子与细胞膜上特异性受体Frizzled蛋白结合激活胞内的d ishevelled(散乱的)蛋白导致GSK3B失活，使α-catenin避免被磷酸化而遭降解的命运 , β-catenin才能在胞质中积累起来。当胞质中B-catenin的浓度达到一定水平
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