ML418,1928763-08-9

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ML418

CAS No. : 1928763-08-9

MCE 国际站：ML418

产品活性：ML418 是一种有效的、选择性的 Kir7.1 钾通道阻滞剂，具有 CNS 穿透性。ML418 可抑制 Kir7.1，IC₅₀ 值为 0.31 μM。ML418 可用于神经、心血管、内分泌和肌肉疾病的研究。

研究领域：Membrane Transporter/Ion Channel

作用靶点：Potassium Channel

In Vitro: ML418 has inhibitory activity for Kir7.1 dose-dependently with an IC₅₀ value of 0.31 μM.
ML418 has selectivity for Kir7.1 and Kir6.2/SUR1 with IC₅₀ values of 1.3 μM and 1.9 μM, respectively.

In Vivo: ML418 (i.p.; 30 mg/kg) has good PK effect, excellent CNS penetration and favorable CNS distribution.

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