- ￥473 - 5413
- MedChemExpress(MCE)
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- 2025年12月05日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
329198-87-0
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg/50 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥780.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥473.0 |
| 规格： | 5 mg | 产品价格： | ￥1100.0 |
| 规格： | 10 mg | 产品价格： | ￥1800.0 |
| 规格： | 25 mg | 产品价格： | ￥3600.0 |
| 规格： | 50 mg | 产品价格： | ￥5413.0 |
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C-178
CAS No. : 329198-87-0
MCE 国际站：C-178
产品活性：C-178 是 STING 的有效和选择性共价抑制剂。C-178 与 Cys91 结合，并抑制小鼠中而非人中由不同的激活剂引起的 STING 反应。
作用靶点：STING
In Vitro: C-178 targets the poorly characterized N-terminal portion of mmSTING that includes the transmembrane domains. Moreover, C-178 interferes with this process by inhibiting the palmitoylation of STING. C-178 does not appreciably affect STING responses in human cells.
C-178 (0-1 μM; 1 hour) alone does not appreciably affect the gene expression profile of BMDMs. In addition, it inhibits the CMA-induced phosphorylation of TBK1.
C-178 (1 μM; 1 hour) decreases cdG, dsDNA, CMA and LPS-induced Ifnb1 expression in mouse bone marrow-derived macrophages.
C-178 (1 μM; 0.5-4 hours) inhibits the CMA-induced p-TBK1 and sting protein expression as a time-dependent manner in mouse embryonic fibroblasts.
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文献和实验Glucose 2.25 g Store at 4 C. 50 mM Tris pH 8.0 10 mM EDTA 50 mM 1 M Tris pH 8.0 5 ml 1 mM 0.5 M EDTA 2 ml H2O up to 100 ml Store at 4 C. 1 M Tris pH 8.0, 1.5 M NaCl 1X 1L 1X 2L 1X 1M Tris-HCl 88.8 g Tris-HCl 178 g 53.0 g
.82.381.2767.43178.1771.22872.43.176.7863.73774.5867.83269.14.071.0960.24371.0964.73666.05.065.21056.95067.01061.24063.06.159.31153.85763.61158.74460.27.353.41250.96559.61255.94857.48.150.012.350.07356.01353.25254.8 8152.51450.75652.4 87.150.014
H2O需多少g? 11.87=(178/358)×X，X=23.87g。 (三)、分别配制缓冲液各100ml(根据需要确定配制的量)。 即：0.2M Na2HPO4·2H2O和NaH2PO4·2H2O100ml。 (四)、按书中的量配制取量再混合。 如：pH=6.8，分别去缓冲对49ml和51ml。 (五)、用pH试纸ceni索赔的缓冲液的pH值，检测配置是否准确。 (六)如配50mM pH =6.8的缓冲液100ml
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