PROTAC Mcl1 degrader-1,2163793

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PROTAC Mcl1 degrader-1

CAS No. : 2163793-38-0

MCE 国际站：PROTAC Mcl1 degrader-1

产品活性：PROTAC Mcl1 degrader-1 (compound C3) 是一种基于 Cereblon 配体的靶向嵌合体的蛋白水解 (PROTAC)，是有效，选择性的 Mcl-1 (Bcl-2 家族成员) 抑制剂，IC₅₀ 为 0.78 μM。PROTAC Mcl1 degrader-1 也抑制 Bcl-2，IC₅₀ 为 0.54 μM。

研究领域：PROTAC  |  Apoptosis

作用靶点：PROTACs  |  Bcl-2 Family

In Vitro: PROTAC Mcl1 degrader-1 (compound C3) induces the ubiquitination and proteasomal degradation of Mcl-1 by introducing the E3 ligase cereblon (CRBN)-binding ligand Pomalidomide (HY-10984) to Mcl-1 inhibitor S1-6 with μM-range affinity.
PROTAC Mcl1 degrader-1 (0-10 μM; 0-24 h) induces selective depletion of Mcl-1 or Bcl-2 protein in HeLa cells in a time- and concentration-dependent manner.
PROTAC Mcl1 degrader-1 (0-2 μM; 24 h) shows cytotoxicity against H23 cells.

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