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- 技术资料
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Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
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货期：1-2天
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10 mM * 1 mL/1 mg/5 mg/10 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥3367.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥1450.0 |
| 规格： | 5 mg | 产品价格： | ￥2900.0 |
| 规格： | 10 mg | 产品价格： | ￥4600.0 |
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LHVS
CAS No. : 170111-28-1
MCE 国际站：LHVS
产品活性：LHVS 是一种有效的，非选择性的，不可逆的，可透过细胞的半胱氨酸蛋白酶 (cysteine protease) 和组织蛋白酶 (cathepsin) 抑制剂。LHVS 可减少肌动蛋白环的形成。LHVS 抑制 T. gondii 侵袭，其 IC50 为 10 μM。
研究领域：Metabolic Enzyme/Protease | Anti-infection
作用靶点：Cathepsin | Parasite
In Vitro: LHVS (5 μM, 2 h) results in a 50% reduction of actin ring formation in wild-type osteoclasts when compared with untreated osteoclasts.
LHVS acts in a dose-dependent manner on osteoclasts and at 5 μM, LHVS inhibits cathepsins K, L, S, and B.
LHVS (1-5 nM) can inhibit specifically cathepsin S in HOM2 cells, leaving other cysteine proteases functionally active.
LHVS impairs tachyzoite attachment by blocking the release of at least two key invasion proteins, MIC2 and M2AP, from the micronemes.
LHVS (50 μM) selectively impairs microneme protein secretion.
In Vivo: LHVS (3-30 mg/kg, SC, once) shows anti-hyperalgesic effect in neuropathic rats.
LHVS (30 nmol per rat, spinal delivery, daily) is antinociceptive in neuropathic rats.
LHVS (1-50 nmol per rat, Intrathecal injection, daily) reverses established neuropathic mechanical hyperalgesia in 14-day neuropathic rats.
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