- ￥2260
- LSM Bio
- 进口
- PAab09861
- 2025年07月13日
- ELISA, WB
- E. coli - derived recombinant protein
- Human, Rat
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
interleukin 4
- 亚型：
IgG
- 形态：
liquid
- 保存条件：
负20摄氏度
- 克隆性：
polyclonal
- 标记物：
Non-conjugated
- 适应物种：
Human, Rat
- 保质期：
6个月
- 抗原来源：
Rabbit
- 目录编号：
Q9BZJ3
- 级别：
纯化级别
- 库存：
50
- 供应商：
LSM bio
- 宿主：
E. coli - derived recombinant protein
- 应用范围：
ELISA, WB
- 浓度：
≥95% as determined by SDS-PAGE
- 靶点：
interleukin 4
- 抗体英文名：
IL-4 antibody
- 抗体名：
IL-4 antibody
- 规格：
100μl
IL-4 antibody
Product Name IL-4 antibody
Catalog No PAab09861
Packing 100ul
Form liquid
Alternative Name BCGF-1
Purification Immunogen affinity purified
Purity 95% as determined by SDS-PAGE
Host Rabbit
Isotype IgG
Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)
Background/ FUNCTION
The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. This gene, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Immunogen interleukin 4
Specificity Human, Rat
Tested Application ELISA, WB
Recommended dilution WB: 1:500 - 1:1000
IHC use
WB use
Transfected HEK-293 cells were subjected to SDS PAGE followed by western blot with PAab09861( IL-4 antibody) at dilution of 1:700
Protein Information
Gene ID 3565
Uniprot ID P05112
Calculated MW Refer to figures
Research Area Immunology, Cardiovascular, Signal Transduction
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文献和实验实验原理 亚适剂量抗IgM抗体对B淋巴细胞的刺激较弱，当加人IL-4时，B淋巴细胞对亚适剂量抗IgM抗体刺激表现出明显的DNA合成增加，3 H-TdR掺人量与IL-4含量相关。 实验步骤 1. 小鼠脾脏B细胞悬液的制备 1) 取BALB／c或C57BL／6小鼠，常规方法分离脾脏淋巴细胞。用Hanks液洗2次；再用10％NBS-IMDM培养液调整细胞浓度为1X107 ～2X107 ／
Generation of Antibody Molecules Through Antibody Engineering
been overcome to a large extent using genetic-engineering techniques to produce chimeric mouse/human and completely human antibodies. Such an approach is particularly suitable because of the domain structure of the antibody molecule ( 2 ), where functional
白细胞介素 IL-4 IL-4主要产生细胞：活化T细胞(Th2)、肥大细胞、嗜酸粒细胞 IL-4氨基酸数目：129 IL-4分子质量(kDa)：18-19 IL-4受体：CDl24；CDl32(γc) IL-4主要生物学活性：促进活化B细胞增殖、分子、Ig产生和类别转换为IgE和IgG1；T细胞生长因子，抑制NK和CTL杀伤活性；促进肥大细胞增殖；增强巨噬细胞功能；协同CSF刺激造血细胞
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