LAT antibody
Product Name LAT antibody
Catalog No PAab10030
Packing 100ul
Form liquid
Alternative Name LAT, LAT1, p36 38, pp36
Purification Immunogen affinity purified
Purity 95% as determined by SDS-PAGE
Host Rabbit
Isotype IgG
Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)
Background/ FUNCTION
Required for TCR(T-cell antigen receptor)-and pre-TCR-mediated signaling, both in mature T-cells and during their development. Involved in FCGR3(low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1(high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules.
Immunogen linker for activation of T cells
Specificity Human
Tested Application ELISA, WB
Recommended dilution WB: 1:500 - 1:2000
IHC use
WB use
Jurkat cells were subjected to SDS PAGE followed by western blot with PAab10030(LAT antibody) at dilution of 1:1000
Protein Information
Gene ID 27040
Uniprot ID O43561
Calculated MW 36-38 kDa
Research Area Immunology, Signal Transduction