- ￥2250
- LSM Bio
- 进口
- PAab10129
- 2025年07月14日
- ELISA, WB, IHC, IF
- E. coli - derived recombinant protein
- Human, Mouse, Rat
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
eukaryotic translation initiation factor 4E binding protein 1
- 亚型：
IgG
- 形态：
liquid
- 保存条件：
负20摄氏度
- 克隆性：
polyclonal
- 标记物：
Non-conjugated
- 适应物种：
Human, Mouse, Rat
- 保质期：
6个月
- 抗原来源：
Rabbit
- 目录编号：
Q9BZJ3
- 级别：
纯化级别
- 库存：
50
- 供应商：
LSM bio
- 宿主：
E. coli - derived recombinant protein
- 应用范围：
ELISA, WB, IHC, IF
- 浓度：
≥95% as determined by SDS-PAGE
- 靶点：
eukaryotic translation initiation factor 4E binding protein 1
- 抗体英文名：
4EBP1 antibody
- 抗体名：
4EBP1 antibody
- 规格：
100μl
4EBP1 antibody
Product Name 4EBP1 antibody
Catalog No PAab10129
Packing 100ul
Form liquid
Alternative Name 4E BP1, 4EBP1, BP 1, eIF4E binding protein 1, EIF4EBP1, PHAS I
Purification Immunogen affinity purified
Purity 95% as determined by SDS-PAGE
Host Rabbit
Isotype IgG
Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)
Background/ FUNCTION
Eukaryotic translation initiation factor 4E-binding protein 1(4EBP1), is a member of 4EBPs family, which regulate the translation of a subset of mRNA by competing with eIF4G for binding to eIF4E, thus preventing the assembly of the eIF4F complex. The eIF4F facilitates the recruitment of other translation initiation factors to form the complex and then initiates cap-dependent translation.4EBP1 also mediates the regulation of protein translation by growth factors, hormones and other stimuli that signal through the MAP kinase and mTORC1 pathways. There are three forms of 4EBP1, alpha, beta and gamma.
Immunogen eukaryotic translation initiation factor 4E binding protein 1
Specificity Human, Mouse, Rat
Tested Application ELISA, WB, IHC, IF
Recommended dilution WB: 1:500-1:1000; IHC: 1:50-1:200; IF: 1:50-1:200
IHC use Immunohistochemistry of paraffin-embedded human breast cancer slide using PAab10129(4EBP1 Antibody) at dilution of 1:50
WB use
MCF7 cells were subjected to SDS PAGE followed by western blot with PAab10129(4EBP1 antibody) at dilution of 1:1000
Protein Information
Gene ID 1978
Uniprot ID Q13541
Calculated MW 17 kDa
Research Area Cancer, Metabolism
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文献和实验Generation of Antibody Molecules Through Antibody Engineering
been overcome to a large extent using genetic-engineering techniques to produce chimeric mouse/human and completely human antibodies. Such an approach is particularly suitable because of the domain structure of the antibody molecule ( 2 ), where functional
The importance of antibody molecules was first recognized in the 1890s, when it was shown that immunity to tetanus and diphtheria was caused by antibodies against the bacterial exotoxins (1 ). Around the same time, it was shown that antisera
General comments: Antibodies, like most proteins, do not like to be freeze-thawed. Avoid repetitive freezing of your solution. The best way to store your antibody is to keep a high protein concentration (>1 mg/ml), add some protease
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