- 询价
- Penncentury
- AP-1 Air Pump
- 美国
- 2026年01月06日
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 询价记录
- 文献和实验
- 技术资料
- 现货状态：
现货
）
可以将精确定量的液体、粉末供试品给到鼠的肺部。
性能特点：
精确定量
较气管内滴入在各肺叶中分布更均匀
直达肺部、易于操作
更安全的提供高浓度
可输送液体、干粉样品
技术参数：
外径：0.64毫米，内径：0.43毫米
弯曲度：120°
Penn-Century MicroSprayer® Aerosolizer - Model IA-1C （liquid）
| part number |
model |
description |
|
|---|---|---|---|
| MSA-250 |
MicroSprayer® Aerosolizer and FMJ-250 High-Pressure Syringe Assembly （Suitable for mouse and larger species） |
Penn-Century MicroSprayer® Syringe Assembly. Includes one standard MicroSprayer® Aerosolizer - Model IA-1C and one FMJ-250 High-Pressure Syringe （required for operation of the MicroSprayer® Model IA-1C）. Standard sizes for mouse （1-1/4"） or for rat （2"） （Please specify）. Both MicroSprayer® and syringe are autoclavable. Each device includes a set of five 25-µl stops and five 50-µl stops for precise dosing of smaller quantities. |
|
| MSA-250-M |
For Mouse |
Standard size for mouse （1.25" after 120-degree bend） |
|
| MSA-250-R |
For Rat |
Standard size for rat: （2" after 120-degree bend） |
|
| MSA-250-C |
Custom Length |
Penn-Century MicroSprayer®/Syringe Assembly. Includes one custom length MicroSprayer® Aerosolizer - Model IA-1C and one FMJ-250 High-Pressure Syringe （required for operation of the Model IA-1C）. MicroSprayer® Aerosolizer can be made to any length or configuration （e.g. short, long, with or without standard 120-degree bend）, as specified by customer. Long lengths may be used with an endotracheal tube or bronchoscope. |
|
| MSA-50 |
MicroSprayer® Aerosolizer and FMJ-50 High-Pressure Syringe Assembly （Suitable for mouse and larger species） |
Penn-Century MicroSprayer® Syringe Assembly. Includes one standard MicroSprayer® Aerosolizer - Model IA-1C and one FMJ-50 High-Pressure Syringe （new product for administration of up to five 10-µl doses） required for operation of the MicroSprayer® Model IA-1C. Standard sizes for mouse （1-1/4"） or for rat （2"） （Please specify）. Both MicroSprayer® and syringe are autoclavable. |
|
| MSA-50-M |
For Mouse |
Standard size for mouse （1.25" after 120-degree bend） |
|
| MSA-50-R |
For Rat |
Standard size for rat: （2" after 120-degree bend） |
|
| MSA-50-C |
Custom Length |
Penn-Century MicroSprayer®/Syringe Assembly. Includes one custom length MicroSprayer®Aerosolizer - Model IA-1C and one FMJ-50 High-Pressure Syringe （required for operation of the Model IA-1C）. Each device includes a set of five 10-µl stops for precise dosing of smaller quantities. MicroSprayer® Aerosolizer can be made to any length or configuration （e.g. short, long, with or without standard 120-degree bend）, as specified by customer. Long lengths may be used with an endotracheal tube or bronchoscope. |
|
| Model IA-1C |
Additional MicroSprayer® Aerosolizers - Standard （Suitable for mice and all larger species.） |
With 23-gauge, stainless steel delivery tube, o.d. of 025" （.64 mm）. NOTE: Must be operated with FMJ-250 High-Pressure Syringe. Standard sizes: 1-1/4" for mouse and 2" for rat after 120-degree bend. Fully autoclavable. |
|
| IA-1C-M |
For Mouse |
Standard size for mouse （1.25" after 120-degree bend） |
|
| IA-1C-R |
For Rat |
Standard size for rat: （2" after 120-degree bend） |
|
| IA-1C-C |
Custom Length |
Custom sizes: any length or configuration （e.g. short, long, with or without standard 120-degree bend）, as specified by customer. Long lengths may be used with an endotracheal tube or bronchoscope. Operated with FMJ-250 High-Pressure Syringe. |
|
^ back to top
Penn-Century High-Pressure Syringes
| part number |
model |
description |
|
|---|---|---|---|
| FMJ-250 |
Additional FMJ-250 High-Pressure Syringe |
Manually-operated, high-pressure syringe required for operating MicroSprayer® Aerosolizer - Model IA-1C. Operates at 3000 psi. Stainless steel construction with glass insert, 250 µl capacity. Replaceable plunger with Teflon® tip. Each device includes a set of five 25-µl stops and five 50-µl stops for precise dosing of smaller quantities. Fully autoclavable. |
|
| PLU-250 |
Replacement Plunger for FMJ-250 |
Replacement plunger for FMJ-250 High Pressure Syringe - with anodized aluminum thumb button and Teflon® tip. |
|
| FMJ-50 |
Additional FMJ-50 High-Pressure Syringe （for precise administration of up to five 10-µl doses） |
New low-dose model. Manually-operated, high-pressure syringe required for operating MicroSprayer® Aerosolizer - Model IA-1C. Operates at 3000 psi. Stainless steel construction with glass insert, 50 µl capacity. Replaceable plunger with Teflon® tip. Each device includes a set of five 10-µl stops for precise dosing of smaller quantities. Fully autoclavable. |
|
| CBA |
Custom Bronchoscopic Adaptor |
NOTE: Longer, straight custom lengths of MicroSprayer® Aerosolizers - Model IA-1C can be ordered for insertion into the working channel of a bronchoscope for administration to a lobe of the lung. Depending on the configuration of the instrument port of the bronchoscope, an adaptor may be required to stabilize the FMJ-250 High Pressure Syringe and prevent bending of the MicroSprayer® during insertion and removal. The adapter must be custom fitted to your equipment in our shop. Please contact us for details. |
|
^ back to top
Penn-Century MicroSprayers® （liquid） - Model IA-1B
| part number |
model |
description |
|
|---|---|---|---|
| Model IA-1B |
MicroSprayer® Aerosolizer with 1 ml disposable polycarbonate syringe （Suitable for rat and all larger species） |
Made with stainless steel 19-gauge delivery tube that measures .048" （1.2 mm） at the very tip. Luer hub. Operates with 1-ml polycarbonate syringe （provided）, or any commercially available 1-ml polycarbonate, or 0.5 ml glass, gas-tight syringe. Fully autoclavable. |
|
| IA-1B-R |
For Rat |
Standard size for rat: （2" after 120-degree bend） |
|
| IA-1B-GP |
For Guinea Pig |
Standard size for guinea pig （3" after 120-degree bend） |
|
| IA-1B-C |
Custom Length |
Custom length MicroSprayer® Aerosolizers are available in any length or configuration （short, long, with or without standard 120-degree bend）. May also be used via an endotracheal tube. Specify dimensions. |
|
^ back to top
Penn-Century Dry Powder Insufflators™
| part number |
model |
description |
|
|---|---|---|---|
| Model DP-4 |
Dry Powder Insufflator™ with disposable 3 ml air syringe |
Made of chemically resistant PEEK™ construction, silicone rubber valves, and hollow stainless steel delivery tube for precise administration of dry powders. Accepts all powder sizes. Air supply: 3 ml disposable air syringe （included）. Standard sizes available for intratracheal administration to rat （2"） or guinea pig （3"）. |
|
| DP-4-R |
For Rat |
Standard size for rat: （2" after 120-degree bend） |
|
| DP-4-GP |
For Guinea Pig |
Standard size for guinea pig （3" after 120-degree bend） |
|
| DP-4-C |
Custom length |
Custom size DP-4 with delivery tube: any length or configuration （straight or with standard 120-degree bend）, as specified by customer. |
|
| DP-EXT-R |
For Rat |
Extra delivery tube for DP-4 for Rat |
|
| DP-EXT-GP |
For Guinea Pig |
Extra delivery tube for DP-4 for Guinea Pig |
|
| DP-EXT-C |
Custom length |
Custom length tips for the Penn-Century Dry Powder Insufflator™ - Model DP-4 may be ordered in any length, straight or with a 120-degree bend, or with custom, flexible delivery tube options. Longer lengths may be inserted into an endotracheal tube or bronchoscope. （Specify dimensions） |
|
| SC-X |
Sample Chamber Extension |
100 mg Sample Chamber Extension - attaches to Model DP-4 for administration of large doses |
|
| DPM-APA |
Penn-Century Dry Powder Insufflator™/Air Pump Assembly for Mouse |
The only light, purely mechanical, manually operated method for intratracheal administration of dry powders to mouse. Includes （1） Penn-Century Dry Powder Insufflator™ for Mouse and （1） Penn-Century Air Pump with adjustable air volume setting （set for mouse at 200 µl）. Insufflator made of chemically resistant PEEK™ construction with removable stainless steel delivery tube sized for intratracheal administration of dry powders to mouse. Operates with spring-loaded, Penn-Century Air Pump for easy, rapid administration of 200 µl pulses of air. |
|
| Model DP-4M |
Additional DP-4M Dry Powder Insufflator™ for Mouse |
Dry Powder Insufflator™ with valve assembly for mouse. PEEK™ construction with silicone rubber valving. Can be used with any animal, including mouse, depending upon delivery tube dimensions. Comes with 23-gauge delivery tube （1.25" after the 120-degree bend）. Operates with spring-loaded, Penn-Century Air Pump for easy, rapid administration of 200 µl pulses of air. |
|
| DPM-EXT |
Extra delivery tube |
Extra delivery tube for DP-4M for Mouse |
|
^ back to top
Penn-Century accessories for precise intratracheal aerosol administration
| part number |
model |
description |
|
|---|---|---|---|
| AP-1 |
Air Pump |
Hand-held precision air pipette with spring-loaded thumb button for easy, fast administration of air pulses. Attaches to any size Penn-Century Dry Powder Insufflator™. Plastic construction with rubber square-ring seal. Outlet: male luer slip. Adjustable air volume setting: 0 - 5 ml. Required for use with DP-4M in mice. Recommended for use in rat, or in other applications requiring rapid dosing of multiple subjects with minimal hand motion. Specify animal to be used. |
|
| LS-2 |
Small-Animal Laryngoscope |
Designed to clearly illuminate the trachea and epiglottis for intubation and insertion of a Penn-Century MicroSprayer® or Dry Powder Insufflator™. Now with a fiberoptic LED light source for clear, bright illumination. Each device comes with a custom-made small, tapered stainless steel blade for moving aside the animal's tongue. （Specify animal when ordering）. New easy-grip handle with curved ergonomic shape fits securely in the palm of the hand. Coated with non-slip Santoprene™ rubber. Operates with one 3-volt lithium battery （included）. Autoclavable. |
|
| LS-2-M |
For Mouse |
With blade sized for use in Mouse |
|
| LS-2-R |
For Rat |
With blade sized for use in Rat |
|
| LS-2-GP |
For Guinea Pig |
With blade sized for use in Guinea Pig |
|
| LS-2-C |
For larger species |
Custom blade for larger species. Please specify when ordering. |
|
| MIP |
Mouse Intubation Platform |
For safe, rapid, easy intratracheal intubation of mice. Adjustable posts for stabilizing anesthestized animal. Unique swiveling neck support permits clearer visualization and access to trachea. Made of sterilizable Plexiglass®/Perspex® with stainless steel and Delrin® fittings. Can be attached to any standard lab clamp stand （not included.） NOTE: $50 discount is offered when Platform is purchased with any Penn-Century MicroSprayer® or Dry Powder Insufflator™. |
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
- 作者
- 内容
- 询问日期
文献和实验Treating Multiorgan Fibrosis
Qiang Long, Zehua Liu, Qianwen Shao, Hongpeng Shi, Shixing Huang, Chenyu Jiang,
Bei Qian, Yiming Zhong, Xiaojun He, Xiaogang Xiang, Yang Yang, Bing Li, Xiaoxiang Yan,
Qiang Zhao,* Xiaoli Wei,* Hélder A. Santos,* and Xiaofeng Ye*
Fibrotic diseases remain a substantial health burden with few therapeutic
approaches. A hallmark of fibrosis is the aberrant activation and accumulation
of myofibroblasts, which is caused by excessive profibrotic cytokines.
Conventional anticytokine therapies fail to undergo clinical trials, as simply
blocking a single or several antifibrotic cytokines cannot abrogate the
profibrotic microenvironment. Here, biomimetic nanoparticles based on
autologous skin fibroblasts are customized as decoys to neutralize multiple
fibroblast-targeted cytokines. By fusing the skin fibroblast membrane onto
poly(lactic-co-glycolic) acid cores, these nanoparticles, termed fibroblast
membrane-camouflaged nanoparticles (FNPs), are shown to effectively
scavenge various profibrotic cytokines, including transforming growth
factor-휷, interleukin (IL)-11, IL-13, and IL-17, thereby modulating the
profibrotic microenvironment. FNPs are sequentially prepared into multiple
formulations for different administration routines. As a proof-of-concept, in
three independent animal models with various organ fibrosis (lung fibrosis,
liver fibrosis, and heart fibrosis), FNPs effectively reduce the accumulation of
myofibroblasts, and the formation of fibrotic tissue, concomitantly restoring
organ function and indicating that FNPs are a potential broad-spectrum
therapy for fibrosis management.
Q. Long, H. Shi, S. Huang, C. Jiang, B. Qian, Y. Zhong, X. He, Q. Zhao,
X. Ye
Department of Cardiovascular Surgery
Ruijin Hospital
Shanghai Jiao Tong University School of Medicine
Shanghai 200025, China
E-mail: zq11607@rjh.com.cn; yxf11612@rjh.com.cn
Z. Liu, H. A. Santos
Department of Biomedical Engineering, W.J. Kolff Institute for
Biomedical Engineering and Materials Science
University Medical Center Groningen/University of Groningen
Ant. Deusinglaan 1, Groningen 9713 AV, The Netherlands
E-mail: h.a.santos@umcg.nl
The ORCID identification number(s) for the author(s) of this article
can be found under https://doi.org/10.1002/advs.202200856
© 2022 The Authors. Advanced Science published by Wiley-VCH GmbH.
This is an open access article under the terms of the Creative Commons
Attribution License, which permits use, distribution and reproduction in
any medium, provided the original work is properly cited.
DOI: 10.1002/advs.202200856
1. Introduction
Fibrosis, or disordered fibrotic tissue formation, is characterized by the abnormal
fibroblast activation that induces excessive extracellular matrix (ECM) remodeling
and primarily accounts for multiple organ
dysfunctions.[1] The pervasive occurrence
of fibrosis in almost all diseases generates
a large healthcare burden worldwide. However, the clinical benefits of antifibrotic therapy through small molecules, such as pirfenidone and nintedanib, are usually offset
by their modest therapeutic efficacy, limited
indications and severe side effects.[2] Therefore, alternative clinical intervention modalities to target fibrosis are urgently needed.
Considering the central role of myofibroblast activation and proliferation in
fibrosis establishment,[3] recent breakthroughs have focused on the ablation
of progressive myofibroblast activation
through autologous cell-based therapy.
For example, autologous chimeric antigen
Z. Liu, H. A. Santos
Drug Research Program
Division of Pharmaceutical Chemistry and Technology
Faculty of Pharmacy
University of Helsinki
Helsinki FI-00014, Finland
Q. Shao, X. Wei
Department of Pharmacology
School of Basic Medical Sciences
Fudan University
Shanghai 200032, China
E-mail: xlwei@fudan.edu.cn
X. Xiang
Department of Infectious Diseases
Ruijin Hospital
Shanghai Jiao Tong University School of Medicine
Shanghai 200025, China
Y. Yang
Department of Thoracic Surgery
Shanghai Pulmonary Hospital
School of Medicine
Tongji University
Shanghai 200000, China
Adv. Sci. 2022, 9, 2200856 2200856 (1 of 14) © 2022 The Authors. Advanced Science published by Wiley-VCH GmbH
技术资料暂无技术资料 索取技术资料
