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- 详细信息
- 文献和实验
- 技术资料
- 供应商:
江西江蓝纯生物试剂有限公司
- 库存:
24
- 克隆性:
单克隆
- 保质期:
1年
- 抗体英文名:
DHX32
- 抗体名:
DHX螺旋酶抗体
- 适应物种:
人/动物/植物
- 应用范围:
WB,ELISA等
- 浓度:
1mg/ml
- 保存条件:
-20 °
- 规格:
100ul/200ul
| 规格: | 100ul | 产品价格: | ¥1580.0 |
|---|---|---|---|
| 规格: | 200ul | 产品价格: | ¥2480.0 |
英文名称 : DHX32
中文名称 : DHX螺旋酶抗体
别 名 : Ddx32; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 32; DEAD/H box 32; DEAD/H helicase like protein 1; DEAH (Asp-Glu-Ala-His) box polypeptide 32; DEAH box protein 32; DHLP1; DHX32; Helicase DDX32; HuDDX32; Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32; DHX32_HUMAN.
研究领域 : 肿瘤 信号转导 表观遗传学
抗体来源 : Rabbit
克隆类型 : Polyclonal
交叉反应 : Human, Mouse, Rat, Dog, Pig, Cow, Rabbit,
产品应用 : WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 : 84kDa
细胞定位 : 细胞核 细胞浆
性 状 : Lyophilized or Liquid
浓 度 : 1mg/ml
免 疫 原 : KLH conjugated synthetic peptide derived from human DHX32:561-660/743
亚 型 : IgG
纯化方法 : affinity purified by Protein A
储 存 液 : 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 : Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed : PubMed
产品介绍 : DEAD-box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp, are putative RNA helicases implicated in several cellular processes involving modifications of RNA secondary structure and ribosome/spliceosome assembly. Based on their distribution patterns, some members of this family may be involved in embryogenesis, spermatogenesis, and cellular growth and division. DDX32 is a 743 amino acid nuclear protein that localizes to the mitochondria and is a member of the DEAD box helicase family. Expressed in various tissues, DDX32 is up-regulated by ionomycin in T lymphocytes and down-regulated in acute lymphoblastic leukemia. Considered a novel RNA helicase, DDX32 may play an important role in the development of colorectal cancer and may be involved in regulating T-cell response to certain apoptotic stimuli.
Function:
DHX32 is a member of the family of the DEAD box proteins, a group of proteins that present the conserved motif Asp-Glu-Ala-Asp (DEAD). They have a role in RNA translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly.
Subcellular Location:
Nucleus. Mitochondrion.
Tissue Specificity:
Expressed in lymphoid tissues (at protein level). Expressed in brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, small intestine, placenta, lung, lymphoid tissues and blood leukocytes.
Similarity:
Belongs to the DEAD box helicase family. DEAH subfamily.
Contains 1 helicase ATP-binding domain.
Contains 1 helicase C-terminal domain.
SWISS:
Q7L7V1
Gene ID:
55760
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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文献和实验施一公团队又出新作!进一步解析人类 U2 snRNP 组装过程,提供癌症突变机制新见解
完成后释放的。而与 DDX42 相反,DDX46 是 17S U2 的一个组成部分,在剪接前体的组装和分支位点的校对过程中发挥着重要作用。但 DDX46 是否在 U2 snRNP 组装中有额外的作用尚不清楚。此外,虽然 DHX15 在内含子-套索剪接体 (ILS) 复合体分解中的机制已被广泛了解,但其在 U2 snRNP 和早期剪接复合体中的作用仍不清晰。 要解决这些关键问题,就必须阐明这些 RNA 解旋酶的结构和功能。最近的研究既揭示了 17S U2 snRNP 的整体结构,也揭示了 SF
致密核心,其实就是病毒的核衣壳。丝状体长短不一,长度有时可达4000nm,直径与球形病毒相同。流感病毒的结构主要包括内部的核心(即核衣壳)和外面的包膜(即病毒囊膜)两部分。 1.核心(核衣壳)流感病毒核心在电子显微镜下呈电子致密的核心,由核蛋白卷曲旋包绕螺旋形RNA组成,其核酸为单股负链RNA,分子量为5.9-6.3×106道尔顿,分节段。甲、乙型流感病毒为8个节段,丙型为7个节段,每一个节段就是一个基因,决定流感病毒的遗传特性,其 基因组 分节段的特点
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