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重组人sRANK受体,Recombinant Human s

RANK Receptor
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  • ¥1140
  • peprotech
  • YJ310-08
  • peprotech
  • 2026年02月25日
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    • 详细信息
    • 文献和实验
    • 技术资料
    • 英文名

      Recombinant Human sRANK Receptor

    • 保质期

      2年

    • 供应商

      上海瓦兰生物

    • 保存条件

      -20°

    • 库存

      大量

    • 规格

      20µg

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    Recombinant Human sRANK Receptor

    产品编号:
    310-08
    别名:
    TNFRSF11A,ODFR (osteoclast differentiation factor receptor),ODAR (osteoclast differentiation and activation receptor),TRANCE Receptor
    描述:
    RANKL and RANK are members of the TNF superfamily of ligands and receptors that play an important role in the regulation of specific immunity and bone turnover. RANK (receptor) was originally identified as a dendritic-cell-membrane protein, which by interacting with RANKL augments the ability of dendritic cells to stimulate naïve T cell proliferation and to promote the survival of RANK + T cells. RANK is also expressed in a variety of tissues including skeletal muscle, thymus, liver, colon, small intestine and adrenal gland. The RANK/RANKL interaction is important in the regulation of osteoclastogenesis and in dendritic-cell-mediated T cell immune responses. Impairments in RANK signaling have been implicated in the induction of expansile osteolysis and Paget disease of bone (PDB2). Recombinant human sRANK receptor is a 19.3 kDa polypeptide containing the TNFR homologous cysteine rich portion of the extracellular domain of RANK receptor (175 amino acid residues).
    氨基酸序列:
    MQIAPPCTSE KHYEHLGRCC NKCEPGKYMS SKCTTTSDSV CLPCGPDEYL DSWNEEDKCL LHKVCDTGKA LVAVVAGNST TPRRCACTAG YHWSQDCECC RRNTECAPGL GAQHPLQLNK DTVCKPCLAG YFSDAFSSTD KCRPWTNCTF LGKRVEHHGT EKSDAVCSSS LPARK
    来源:
    E.coli
    纯度:
    Greater than 98% by SDS-PAGE gel and HPLC analyses.
    生物活性:
    Determined by its ability to inhibit sRANKL induced NFkappaB in RAW264.7 cells in the absence of any cross-linking. The expected ED50 for this effect in the presence of 15ng/ml of recombinant sRANKL, is 30-50 ng/ml.

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