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- 2025年12月05日
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- 保存条件：
4°C, stored under nitrogen
- 库存：
货期：1-2天
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MedChemExpress LLC
- CAS号：
2230836-55-0
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥1730.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥723.0 |
| 规格： | 5 mg | 产品价格： | ￥1700.0 |
| 规格： | 10 mg | 产品价格： | ￥2700.0 |
| 规格： | 25 mg | 产品价格： | ￥4788.0 |
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BI-3406
CAS No. : 2230836-55-0
MCE 国际站：BI-3406
产品活性：BI-3406 (compound I-6) 是一种具有口服活性，高效且选择性的 KRAS-SOS1 抑制剂，可抑制 KRAS 与 SOS1 之间相互作用，IC50 为 6 nM。BI-3406 有效地减少了 GTP 加载的 KRAS 的形成，并抑制了 MAPK 信号通路。BI-3406 具有抗癌活性。
研究领域：GPCR/G Protein | MAPK/ERK Pathway
作用靶点：Ras | p38 MAPK
In Vitro: BI-3406 is an inhibitor of the interaction between KRAS and its Guanine Nucleotide Exchange Factor (GEF) SOS1. BI-3406 does not block the interaction of KRAS with SOS2 but elicits activity on a broad panel of KRAS oncogenic variants, including all major G12 and G13 oncoproteins. Down-modulation of this signaling cascade by BI-3406 in KRAS G12 or G13 mutant cells effectively limits cell proliferation.
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