G6PD activator AG1,421581-52-4

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G6PD activator AG1

CAS No. : 421581-52-4

MCE 国际站：G6PD activator AG1

产品活性：G6PD activator AG1 是一种有效的选择性 6-磷酸葡萄糖脱氢酶 (G6PD) 激动剂，EC₅₀ 为 3 µΜ。G6PD activator AG1 可以减少人红细胞的溶血。

研究领域：Others

作用靶点：Others

In Vitro: AG1 (50, 100, 250, 500, 750, 1000 nM) of 1?μM increases the viability by 20% and the proteolytic stability of Canton G6PD in SH-SY5Y cells. AG1 has no effect when G6PD was knocked down by siRNA, supporting the specificity of AG1 toward G6PD.
AG1 (1-5 μΜ; pre-incubated overnight) reduces the extent of hemolysis with 5 μΜ in human erythrocytes suspension (5%) exposed to either 1 mM chloroquine (CQ; 4 hours) or diamide (a GSH oxidant; 4 hours). AG1 increases GSH levels and reduced ROS levels together with increased G6PD activity under these drug-induced oxidative stress.
AG1 has no effect on the dimerization or activity of several other NAD- or NADP+-dependent dimeric or tetrameric enzymes, including 6-phosphogluconate dehydrogenase (6PGD), glyceraldehyde 3-phosphate dehydrogenase (GAPDH), aldehyde dehydrogenase 2 (ALDH2), and aldehyde dehydrogenase 3A1 (ALDH3A1).

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