Tuvusertib,1613200-51-3

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Tuvusertib

CAS No. : 1613200-51-3

MCE 国际站：Tuvusertib

产品活性：Tuvusertib (M1774; ATR inhibitor 1) 是一种选择性和具有口服活性的 ATR 抑制剂，K_i 值低于 1 μΜ，详细信息请参考专利 WO2015187451A1，化合物 I-l。

研究领域：Cell Cycle/DNA Damage  |  PI3K/Akt/mTOR

作用靶点：ATM/ATR

In Vitro: Tuvusertib (0-2 μM, 24 h) induces cell death and cell apoptosis in myeloma cells (such as U266 and OPM2 cells).
Tuvusertib (0-5 μM, 16 or 24 h) inhibits STAT3 p-Y705 phosphorylation and down-regulates STAT3 downstream targets (c-MYC) in U266 and OPM2 cells.

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