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- 详细信息
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
4-Hydroxy-L-isoleucine
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
781658-23-9
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/20 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥550.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥250.0 |
| 规格： | 5 mg | 产品价格： | ￥500.0 |
| 规格： | 10 mg | 产品价格： | ￥800.0 |
| 规格： | 20 mg | 产品价格： | ￥1250.0 |
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4-Hydroxyisoleucine
CAS No. : 781658-23-9
MCE 国际站：4-Hydroxyisoleucine
产品活性：4-Hydroxyisoleucine 是可以从胡芦巴种子中分离得到的一种具有口服活性的氨基酸。4-Hydroxyisoleucine 具有促胰岛素和抗糖尿病的特性。
研究领域：Others
作用靶点：Others
In Vitro: 4-Hydroxyisoleucine (20 μM, 6 h) decreases the level of iRhom2, TACE, TNF-α and MCP-1 in RAW264.7 macrophages and 3 T3-L1 adipocytes with LPS (HY-D1056) induction.
4-Hydroxyisoleucine (20 μM, 6 h) increases the product of M1 macrophage IL-6 and decreases the product of M2 macrophage IL-10 in the co-culture system with LPS (HY-D1056) stimulation.
4-Hydroxyisoleucine (0-25 μM, 16 h) increases glucose uptake and surface GLUT4myc level in L6-GLUT4myc myotubes in a concentration-dependent manner.
4-Hydroxyisoleucine (0-25 μM, 16 h) stimulates GLUT4myc translocation via PI-3-K/AKT-dependent mechanisms in L6-GLUT4myc myotubes.
In Vivo: 4-Hydroxyisoleucine (50 mg/kg, p.o., daily, 8 weeks) inhibits the increase in serum glucose in the fructose-fed rat model of metabolic syndrome.
4-Hydroxyisoleucine (200 mg/kg, p.o., 8 weeks) improves dyslipidemia and reduces lipid ectopic accumulation in C57BL/6 mice.
4-Hydroxyisoleucine (200 mg/kg, p.o., 8 weeks) decreases the expression of proinflammatory cytokine (IL-6, PAI-1, IL-1β, NF-κB, TNF-α, and MCP-1) and the proportion of proinflammatory M1 macrophages in C57BL/6 mice.
4-Hydroxyisoleucine (50 mg/kg, i.g., daily, 14 days) restores high levels of lipids (cholesterol, HDL, LDL and triglycerides) and uric acid in type 1 diabetic rat to that of nondiabetic controls level.
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