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- 2025年12月05日
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- 保存条件：
4°C, protect from light
- 库存：
货期：1-2天
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MedChemExpress LLC
- CAS号：
144506-15-0
- 规格：
1 mg/2 mg/5 mg/10 mg
| 规格： | 1 mg | 产品价格： | ￥913.0 |
|---|---|---|---|
| 规格： | 2 mg | 产品价格： | ￥1551.0 |
| 规格： | 5 mg | 产品价格： | ￥2900.0 |
| 规格： | 10 mg | 产品价格： | ￥4200.0 |
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Licochalcone D
CAS No. : 144506-15-0
MCE 国际站：Licochalcone D
产品活性：Licochalcone D 是存在于 Glycyrrhiza uralensis 中的黄酮类化合物，是具有口服活性的 NF-κB p65 的有效抑制剂。Licochalcone D 具有抗氧化、抗炎、抗癌等作用。
研究领域：NF-κB | Apoptosis | Immunology/Inflammation | Metabolic Enzyme/Protease
作用靶点：NF-κB | Apoptosis | Reactive Oxygen Species
In Vitro: Licochalcone D (10 μM; 1 h) negatively regulates Lipopolysaccharides (LPS) (HY-D1056)-induced NF-κB activation by inhibiting the phosphorylation and transactivation of NF-κB p65, inhibits the LPS-induced activation of protein kinase A (PKA), and significantly inhibits the LPS-induced expression of TNFα and MCP-1.
?Licochalcone D (10 μM; 24 h) significantly inhibits LPS-induced iNOS expression and NO production.
?Licochalcone D (0-90 μM; 24 h) inhibits the proliferation of human melanoma cells, induces the apoptosis of A375 cells, decreases the mitochondrial membrane potential and increases ROS production in A375 cells.
?Licochalcone D (0-25 μM; 24 h) decreases the migration and invasion ability of the A375 cells, decreased the protein levels of MMP-2 and MMP-9.
In Vivo: Licochalcone D (25 and 50 mg/kg; i.g.; daily for a week) inhibits the tumor growth in a mouse xenograft model of murine melanoma B16F0 cells.
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文献和实验慢性胃炎 的患者，进行辨证分型，并等分为两组。对照组：脾胃虚弱型用四君子合 黄芪 建中汤为主；肝胃失和型用四逆散为主；脾胃湿热型用藿朴夏芩汤为主。治疗组：按上述分型用药的基础上加入对Hp抗菌有效的制大黄、黄连、黄芩和生甘草。均为水煎剂，每日1剂，每日2次，7d为1疗程，服用8～12疗程。3个月后复查胃镜，尿素酶试验、病理检查和Hp涂片检查。结果治疗组的Hp清除有效率明显优于对照组。由此可见在辨证的基础上加用对Hp有抗菌作用的有效中草药疗效优于单纯辨证用药
率、复发率三方面，治疗组分别为2.85d±1.15d，87.9％，6.9％，对照组分别为7.85d±2.56d，50％，46.7％，两组差异显著。 徐永正对20例活动性消化性溃疡采用锡类散胃镜下直接喷涂合小剂量雷尼替丁口服治疗，并与22例单服雷尼替丁组进行对比观察，疗效较满意。两组用药时间均为4周，治疗组胃镜内给药2次。治疗期间停用其它抗溃疡及止酸等药物。治疗组与对照组的溃疡愈合率、Hp转阴情况分别为91.6％（11/13）例和57.1％，（2/15）例，两组间有显著差异。治疗
，每日3次，饭前冲服5周～6周为1疗程，可连续使用2～3个疗程。二白理胃散由白芍、白芨、香附、生甘草各等份晒干碾粉末或碾蜜为丸。每次10g，饭后服用，每日3次。服药2d后上腹部疼痛逐渐消失或减轻。用药期间禁食辛辣、生硬之品。 2 疗效标准及结果 痊愈：溃疡面消失或仅留疤痕。显效：溃疡面缩小在一半以上，或溃疡面干净仅有少许白苔。无效：溃疡面无变化或扩大、或恶化。在32例中，治愈24例，治愈率达75％，显效8例，总有效率为100％。 典型病例 男，48岁，已婚
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