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-20°C, stored under nitrogen
- 库存：
货期：1-2天
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MedChemExpress LLC
- CAS号：
473-15-4
- 规格：
1 mg/5 mg/10 mg/25 mg/50 mg
| 规格： | 1 mg | 产品价格： | ￥600.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥1400.0 |
| 规格： | 10 mg | 产品价格： | ￥2200.0 |
| 规格： | 25 mg | 产品价格： | ￥3600.0 |
| 规格： | 50 mg | 产品价格： | ￥5000.0 |
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Beta-Eudesmol
CAS No. : 473-15-4
MCE 国际站：Beta-Eudesmol
产品活性：Beta-Eudesmol 具有抗癌、抗炎活性。Beta-Eudesmol 能够诱导细胞凋亡。Beta-Eudesmol 可以拮抗新斯的明诱导的神经肌肉衰竭。Beta-Eudesmol 可以用于脓毒症、神经肌肉衰竭等疾病的研究。Beta-Eudesmol 是可以从苍术的根茎中提取得到的类倍半萜烯化合物。
研究领域：Apoptosis | Immunology/Inflammation | Metabolic Enzyme/Protease | NF-κB
作用靶点：Caspase | TNF Receptor | SOD | Reactive Oxygen Species
In Vitro: Beta-Eudesmol (30-100 μM; 6 days) can inhibit the cell proliferation induced by vascular endothelial growth factor (VEGF) (30 ng/ml) and basic fibroblast growth factor (bFGF) (30 ng/ml) in HUVEC cells, thereby inhibiting angiogenesis.
Beta-Eudesmol (10-100 μM; 72 h) inhibits cell proliferation in a time- and dose-dependent manner in tumor in tumer cells HeLa, SGC-7901 and BEL-7402.
Beta-Eudesmol (10-120 μM; 4 h) can reduce cell activity in HL-60 cells.
Beta-Eudesmol (40-80 μM; 4 h) can activate caspase-3 by inducing the release of cytochrome c, thereby inducing cell apoptosis in HL-60 cells.
In Vivo: Beta-Eudesmol (2.5-5 mg/kg; Intraperitoneal injection; Once daily for 7 days) significantly inhibits tumor cell and new blood vessel generation in MK mice.
Beta-Eudesmol (50-100 mg/kg; Intraperitoneal injection; Single dose) can inhibit the NF-κb signaling pathway and has anti-inflammatory and antioxidant effects in C57BL/6 mice.
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文献和实验(Ser645) expression, andincreases in the total level of β-catenin and glycogen synthase protein expression were observed . 1.1.1. Inorganic Elements as Inhibitors of GSK-3 Lithium was the first discovered GSK-3 inhibitor (15
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