Concanamycin A刀豆素A,80890-47-7

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Concanamycin A

CAS No. : 80890-47-7

MCE 国际站：Concanamycin A

产品活性：Concanamycin A (Folimycin; Antibiotic X 4357B) 是一种大环内酯类抗生素，是空泡状 H⁺-ATP 酶 (V-ATPase) 抑制剂。Concanamycin A 是一种溶酶体酸化抑制剂，可用于 T 细胞介导的炎症研究。

研究领域：Membrane Transporter/Ion Channel  |  Anti-infection

作用靶点：Proton Pump  |  Bacterial  |  Antibiotic

In Vitro: Concanamycin A can come from S. diastatochromogenes, as a microbial metabolite with immunomodulatory activity.
?Concanamycin A (100 nM; 0-20 h) results DNA fragmentation in CD4⁺ and selectively induces CD8⁺ T cells rapid cell death between normal and the immunized mice source, while CD8⁺ population in mice immunized is more sensitive.
?Concanamycin A (3-50 nM; 16 h) inhibits LPS-induced NO production in elicited peritoneal macrophages, but (25 nM; 7 h) doesn’t inhibit LPS-induced TNF-α production.
?Concanamycin A (0.01 nM-1 nM) inhibits the acidification of rat liver lysosomes (IC₅₀ =0.061 nM), and inhibits oleate incorporation into cholesteryl ester (IC₅₀ =14 nM).

In Vivo: Concanamycin A (15 mg/kg; i.v.; 0, 10 or 24 h prior to sacrifice) induces T cell-mediated hepatitis in mice.

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