Bilobetin白果素,521-32-4

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Bilobetin

CAS No. : 521-32-4

MCE 国际站：Bilobetin

产品活性：Bilobetin 是一种 Ginkgo biloba 活性成分，可以降低血脂，改善胰岛素的作用。 Bilobetin 改善胰岛素抵抗，增加肝脏对脂质的吸收和氧化，降低极低密度脂蛋白甘油三酯分泌和血液甘油三酯水平，增强组织中 β-氧化的酶的表达和活性，并减弱甘油三酯及其代谢产物的积累。Bilobetin 还增加了 PPARα 的磷酸化，核转位和活性，同时伴随着 cAMP 水平和 PKA 活性的升高。

研究领域：Cell Cycle/DNA Damage  |  Vitamin D Related/Nuclear Receptor  |  Stem Cell/Wnt  |  PI3K/Akt/mTOR  |  MAPK/ERK Pathway

作用靶点：PPAR  |  PKA  |  Akt  |  p38 MAPK  |  ERK

In Vitro: Bilobetin (0-40 μM, 24/48/72 h) inhibits the cell proliferation in Huh7 and HepG2 cells.
Bilobetin (0-20 μM, 24 and 48 h) induces apoptosis and increases sub G1 population in Huh7 and HepG2 cells.
Bilobetin (0-20 μM, 24 h) induces accumulation of ROS and DNA damage in Huh7 and HepG2 cells.
Bilobetin (1-2 μM, 1 days) inhibits the phosphorylation of AKT in sebocytes.

In Vivo: Bilobetin (i.p., 12 mg/kg/day, 4 or 14 days) ameliorates hyperlipidaemia, lipotoxicity and insulin resistance by PKA-mediated phosphorylation of PPARα in rats fed a high-fat diet.
Bilobetin (i.p., 50 mg/kg, for 7 days) induces kidney injury in rats, and promotes the trafficking of AQP-2 onto the plasma membrane in rats.
Bilobetin (6 and 12 mg/kg, i.p., daily for ten days.) shows protective effects against Cisplatin (HY-17394) (7 mg/kg, i.p., a single dose on the third day)-induced testicular toxicity in rats.

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