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- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
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MedChemExpress LLC
- CAS号：
58479-68-8
- 规格：
10 mM * 1 mL/5 mg/10 mg/25 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥660.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥600.0 |
| 规格： | 10 mg | 产品价格： | ￥990.0 |
| 规格： | 25 mg | 产品价格： | ￥1732.0 |
| 规格： | 50 mg | 产品价格： | ￥2700.0 |
| 规格： | 100 mg | 产品价格： | ￥4050.0 |
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Platycodin D
CAS No. : 58479-68-8
MCE 国际站：Platycodin D
产品活性：Platycodin D 是可从桔梗中分离得到的皂苷类化合物，为 AMPKα 的激活剂，具有抗肥胖活性。WNT/β-catenin 通路介导 Platycodin D 的抗成脂作用。
研究领域：Epigenetics | PI3K/Akt/mTOR | Stem Cell/Wnt
In Vitro: Platycodin D (4 μM; 24 h) increases gene expressions of Ucp1, Pgc1a, Sirt3, Cytc, Nrf1 and Prdm16, and suppresses expressions of adipokine genes Fabp4, Adipoq, Lipin1 in 3T3-L1 adipocytes and FABP4, ADIPOQ and RESISTIN in hAMSCs.
Platycodin D (2 and 10 μM) suppresses lipid accumulation in murine and human adipocytes respectively.
Platycodin D suppresses the protein expressions of PPARγ and C/EBPα, and increases protein expressions of UCP1, PGC1α, SIRT3, CIDEA and LIPIN1.
Platycodin D (10 μM) inhibits lipid droplet formation, and reduces the expression of the FABP4 protein involved in lipid metabolism and the expressions of PPARγ and C/EBPα.
Platycodin D (10 μM; 0-7 d) recoveres CCND1 mRNA level and increases PPARδ level.
In Vivo: Platycodin D (5 mg/kg; oral administration, 5 times per week for 5 weeks) decreases the body weight of obese mice.
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文献和实验为1.18％。结论通过6批不同的桔梗提取物的含量测定，证明该方法简便、准确、可靠。 【关键词】 桔梗提取物； 桔梗皂苷D； 反相高效液相色谱法； 蒸发光散射检测 Abstract：ObjectiveTo establish an RP-HPLC determination method of the platycodin D in Platycodon Grandiflorum extracts. MethodsPlatycodin D content was detected
[3H](+)MK801 Radioligand Binding Assay at the N‐Methyl‐D‐Aspartate Receptor
., Siegel, B.W., Harrison, B.L., Gross, R.S., Hawes, C., and Towers, P. 1996. [3H]MDL 105,519, a high‐affinity radioligand for the N‐methyl‐D‐aspartate receptor‐associated glycine recognition site J. Pharmacol. Exp. Ther. 279:62‐68
减肥新纪元！NEJM、JAMA 力挺这种糖尿病治疗药物用于减肥！
.3 kg，平均 BMI 37.9，平均腰围 114.7 cm。志愿者详细临床信息见下表。 图片来源：NEJM随后，志愿者接受每周 2.4 mg 剂量的 Semaglutide 或匹配的安慰剂进行皮下注射，整个过程持续 68 周。同时，在这个 68 周的周期之后是 7 周的周期，这 7 个周期所有志愿者均没有接受 Semaglutide 或安慰剂或其他生活方式的干预，以此评估前期减肥是否具有反弹。借助智能手机应用程序或其他工具，所有参与者每天的饮食和活动都被记录。Semaglutide 可有效降低
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