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- 2025年12月05日
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-20°C, protect from light
- 库存：
货期：1-2天
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MedChemExpress LLC
- CAS号：
35286-59-0
- 规格：
5 mg/10 mg
| 规格： | 5 mg | 产品价格： | ￥550.0 |
|---|---|---|---|
| 规格： | 10 mg | 产品价格： | ￥950.0 |
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Ziyuglycoside II
CAS No. : 35286-59-0
MCE 国际站：Ziyuglycoside II
产品活性：Ziyuglycoside II 是从 Sanguisorba officinalis L. 中提取的三萜皂苷化合物。Ziyuglycoside II 诱导活性氧 (ROS) 产生和凋亡 (apoptosis)。 具有抗炎和抗癌作用。
研究领域：Immunology/Inflammation | NF-κB | Metabolic Enzyme/Protease | Apoptosis
作用靶点：Reactive Oxygen Species | Apoptosis
In Vitro: Ziyuglycoside II (10-60 μM; 24 h and 48 h) inhibits MDA-MB-435 cells growth in a dose-dependent manner. The IC50 of Ziyuglycoside II at 24 h and 48 h is 5.92 μM and 4.74 μM, respectively.
?Ziyuglycoside II (5-25 μM) induces G0/G1 and S phase arrest in MDA-MB-435 cells at 24 h.
?Ziyuglycoside II (5-25 μM; 24 hours) significantly increases apoptotic rate of MDA-MB-435 cells.
?Ziyuglycoside II (5-25 μM; 24 hours) increases expressions of both p53 and p21 in MDA-MB-435 cells, which effect is dose-dependent.
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文献和实验【1】，Stem cells and development【2】、Development【3】、Current Protocols in Stem Cell Biology【4】发表的四篇文章，整理了人类胚胎干细胞（human ESCs）来源的心脏类器官培养方案。 图1. hESCs来源的hCOs培养方案【1】 细胞来源 Human ESCs 培养基配方 MEFs 培养基 ESCs 培养基 中胚层培养基 心肌分化培养基（I） 心肌分化培养基（II） 心肌分化培养
In Vitro Techniques for Studies of HIV-1 Promoter Activity
-1) (see refs. 2 and 3 ). IST directs the RNA polymerase II to synthesize short (59–61 nt), correctly initiated, nonpolyadenylated transcripts that prematurely terminate at the TAR stem-loop structure. The function of these transcripts remains unclear (see ref. 4 ).
Genome-Wide Overexpression Screen for Activators of Antioxidant Gene Transcription
that leads to transcriptional activation of the antioxidant response element (ARE). The ARE is located in the 59-flanking regions of many phase II detoxification and antioxidant enzymes such as NAD(P)H:quinone oxidoreductase 1 (NQO1) and regulates
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