- ￥495 - 6500
- MedChemExpress(MCE)
- 美国
- HY-15404
- 2025年07月08日
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years. In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
Lu-135252
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
171714-84-4
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/50 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥1430.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥495.0 |
| 规格： | 5 mg | 产品价格： | ￥1300.0 |
| 规格： | 10 mg | 产品价格： | ￥2200.0 |
| 规格： | 50 mg | 产品价格： | ￥6500.0 |
MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。
Darusentan
CAS No. : 171714-84-4
MCE 国际站：Darusentan
产品活性：Darusentan (Lu-135252) 是一种选择性内皮素受体 A (ET-A) 受体拮抗剂，其与 ET-A 受体的 Ki 为 1.4 nM，与 ET-B 受体的 Ki 为 184 nM，对 ETA 受体的选择性比 ETB 受体高100多倍。Darusentan 在大鼠主动脉血管平滑肌细胞 (RAVSMs) 膜中竞争结合放射性标记的内皮素，Ki 为 13 nM。
研究领域：GPCR/G Protein
作用靶点：Endothelin Receptor
In Vitro: Darusentan ((S)-Darusentan) competes for radiolabeled endothelin binding in rat aortic vascular smooth muscle cells (RAVSMs) membranes with single-site kinetics, exhibiting a Ki=13 nM. In isolated endothelium-denuded rat aortic rings, Darusentan inhibits endothelin-induced vascular contractility with a pA2=8.1±0.14. Darusentan ( 0.001-1μM) inhibits ET-1-induced signaling in cultured RAVSMs.
In Vivo: Darusentan (30 mg/kg per day orally for weeks 3 and 4) reverses aortic alterations produced by infusion of Norepinephrine (2.5 μg/kg per min subcutaneously for 2 and 4 weeks) in male Sprague Dawley rats.
相关产品：Drug Repurposing Compound Library Plus | Clinical Compound Library Plus | Bioactive Compound Library Plus | GPCR/G Protein Compound Library | Clinical Compound Library | Drug Repurposing Compound Library | Anti-Cardiovascular Disease Compound Library | Endocrinology Compound Library | Orally Active Compound Library | Neurotransmitter Receptor Compound Library | Angiogenesis-Related Compound Library | Coagulation and Anti-coagulation Compound Library | Heterocyclic Compound Library | Pain-Related Compound Library | Antihypertensive Compound Library | Membrane Protein-targeted Compound Library | Membrane Receptor-targeted Compound Library | Highly Selective Inhibitors Library | Endothelin 1 (swine, human) | Bosentan | Macitentan | Ambrisentan | Atrasentan hydrochloride | BQ-123 | BQ-788 | Carperitide acetate | Atrial Natriuretic Peptide (ANP) (1-28), rat | Sulfisoxazole | Endothelin-3, human, mouse, rabbit, rat TFA | Sparsentan | Zibotentan | A-192621 | Sitaxsentan sodium | IRL-1620 TFA | Clazosentan | Nebentan potassium | Avosentan | Aprocitentan | Tezosentan | IRL 2500
热门产品线：重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物
Trending products：Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Dye Reagents | PROTAC | Isotope-Labeled Compounds
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
技术资料暂无技术资料 索取技术资料
