CHPG,170846-74-9

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CHPG

CAS No. : 170846-74-9

MCE 国际站：CHPG

产品活性：CHPG 是一个选择性的 mGluR5 激动剂，并且通过 TSG-6/NF-κB 途径减弱 BV2 小神经胶质细胞 SO₂ 诱导的氧化应激和炎症。 CHPG 通过 ERK 和 Akt 途径在体外和体内预防创伤性脑损伤 (TBI)。

研究领域：GPCR/G Protein  |  Neuronal Signaling  |  NF-κB  |  Stem Cell/Wnt  |  MAPK/ERK Pathway  |  PI3K/Akt/mTOR

作用靶点：mGluR  |  NF-κB  |  ERK  |  Akt

In Vitro: CHPG (10-500 µM; 24 hours) significantly increases the cell viability and decreases the LDH release after SO₂ derivatives treatment.
CHPG (0.5 mM; 30 mins ) protects BV2 cells against SO₂-induced apoptosis.
CHPG (0.5 mM; 30 mins) treatment alone increases the expression of TSG-6 in both mRNA and protein levels.

In Vivo: CHPG (injection; 250 nM; for 7 days) reduces significantly cerebral lesion volume.

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