PROTAC AR Degrader-4,1351169-3

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PROTAC AR Degrader-4

CAS No. : 1351169-31-7

MCE 国际站：PROTAC AR Degrader-4

产品活性：PROTAC AR Degrader-4 包含 IAP 配体结合基团，linker 和雄激素受体 (AR) 配体结合基团。基于 cIAP1 的降解剂也被称为 SNIPER。

研究领域：PROTAC  |  Vitamin D Related/Nuclear Receptor

作用靶点：SNIPERs  |  PROTACs  |  Androgen Receptor

In Vitro: Specific and Nongenetic IAPs-dependent Protein Erasers (SNIPERs) are bifunctional compounds which are designed by conjugating an IAPs-recognition structure with a target protein-recognition structure.
Targeting proteins for degradation involves three steps.
1, its two recognition structures allow SNIPER to form a complex linking IAPs, which have E3 ligase activity, with the target protein.
2, the target protein is polyubiquitinated by IAPs.
3, the polyubiquitinated protein is degraded by proteasome.

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