In Vitro: NSC-87877 (0-0.5 μM, 5 days) inhibits DUSP26 function in NB cell lines. ?NSC-87877 (0-0.5 μM, 5 days) results in increased p53 phosphorylation (Ser37 and Ser46) and activation.
In Vivo: NSC-87877 (30?mg/kg, IP once daily for 15 days) possesses excellent anti- neuroblastoma activity.