- ¥1580
- gelatins
- jlcR22137
- 国内
- 2025年07月11日
- WB,ELISA等
- 人/动物/植物
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 文献和实验
- 技术资料
- 供应商：
江西江蓝纯生物试剂有限公司
- 库存：
144
- 克隆性：
单克隆
- 保质期：
1年
- 抗体英文名：
LPA1
- 抗体名：
溶血磷脂酸受体蛋白1/EDG2抗体
- 适应物种：
人/动物/植物
- 应用范围：
WB,ELISA等
- 浓度：
1mg/ml
- 保存条件：
-20 °
- 规格：
100ul
英文名称 : LPA1
中文名称 : 溶血磷脂酸受体蛋白1/EDG2抗体
别 名 : EDG 2; Endothelial Cell Differentiation Gene-2; Endothelial differentiation gene 2; Endothelial Differentiation Lysophosphatidic Acid G Protein Coupled Receptor 2; G10 protein homolog; GPCR 26; GPCR26; Gpcr91; Kdt2; LPA 1; LPA receptor 1; LPA receptor EDG2; LPA1; LPAR1; Lysophosphatidic acid receptor 1; Lysophosphatidic acid receptor EDG2; MGC105279; MGC29102; LPAR1_HUMAN.
研究领域 : 肿瘤 免疫学 信号转导 G蛋白偶联受体
抗体来源 : Rabbit
克隆类型 : Polyclonal
交叉反应 : Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Sheep,
产品应用 : IHC-P=1:400-800 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 : 41kDa
细胞定位 : 细胞浆 细胞膜
性 状 : Lyophilized or Liquid
浓 度 : 1mg/ml
免 疫 原 : KLH conjugated synthetic peptide derived from human LPA1:1-50/364 <Extracellular>
亚 型 : IgG
纯化方法 : affinity purified by Protein A
储 存 液 : 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 : Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed : PubMed
产品介绍 : EDG2 belongs to a family of G-protein coupled receptors whose ligands are lysophospholipids. There are eight known members of the EDG receptor family and they are implicated in mediating growth-related effects such as induction of cellular proliferation, alterations in differentiation and survival, and suppression of apoptosis. They also evoke cellular effector functions that are dependent on cytoskeletal responses such as contraction, secretion, adhesion and chemotaxis. EDG receptors are developmentally regulated and differ in tissue distribution. They couple to multiple types of G proteins to signal through ras and MAP kinase, rho, phospholipase C, and several proteins not used within 12 hours. Edg2 has been reported in most human tissues, and is especially abundant in brain cortical regions. ESTs have been isolated from bone, brain, breast, connective tissue, embryo, heart/melanocyte/uterus, lung, prostate and uterus libraries.
Function:
Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Stimulates phospholipase C (PLC) activity in a manner that is dependent on RALA activation.
Subunit:
Interacts with RALA and ADRBK1.
Subcellular Location:
Cell surface. Cell membrane; Multi-pass membrane protein. Note=Prior to LPA treatment found predominantly at the cell surface but in the presence of LPA co-localizes with RALA in the endocytic vesicles.
Tissue Specificity:
Expressed in many adult organs, including brain, heart, colon, small intestine, placenta, prostate, ovary, pancreas, testes, spleen, skeletal muscle, and kidney. Little or no expression in liver, lung, thymus, or peripheral blood leukocytes.
Similarity:
Belongs to the G-protein coupled receptor 1 family.
SWISS:
Q92633
Gene ID:
1902
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品图片
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验质、DNA和RNA合成中起作用。锰在自然界分布广泛，以茶叶中含量最丰富。镁的缺乏较少。若吸收过多可出现中毒症状，主要由于生产及生活中防护不善，以粉尘形式进入人体所致。锰是一种原浆毒，可引起慢性神经系统中毒，表现为锥体外系的功能障碍。并可引起眼球集合能力减弱，眼球震颤、睑裂扩大等。 五、硒 硒是人体必需的一种微量元素，体内含量约14-21mg，广泛分布于除脂肪组织以外的所有组织中。主要以含硒蛋白质形式存在。人体每日硒的需要量为50－200μg。 硒是谷胱甘肽过氧化物酶(GSH�x
质、DNA和RNA合成中起作用。锰在自然界分布广泛，以茶叶中含量最丰富。镁的缺乏较少。若吸收过多可出现中毒症状，主要由于生产及生活中防护不善，以粉尘形式进入人体所致。锰是一种原浆毒，可引起慢性神经系统中毒，表现为锥体外系的功能障碍。并可引起眼球集合能力减弱，眼球震颤、睑裂扩大等。 五、硒 硒是人体必需的一种微量元素，体内含量约14-21mg，广泛分布于除脂肪组织以外的所有组织中。主要以含硒蛋白质形式存在。人体每日硒的需要量为50－200μg。 硒是谷胱甘肽过氧化物酶(GSH�x
相关，负责组蛋白乙酰化和去乙酰化的是一对功能相互拮抗的蛋白酶――组蛋白乙酰化酶（HAT）和去乙酰化酶（HDAC）。HAT对组蛋白乙酰化可中和组蛋白电荷，使DNA结构松散、开放，便于转录因子及RNA聚合酶更加接近DNA，促进基因表达；而HDAC的作用相反，组蛋白去乙酰化使DNA更加紧密，抑制基因表达。HDAC还参与细胞周期的调控，其中RB对转录因子E2F的转录抑制就是通过募集HDAC实现的。 （二）肿瘤分化的标志 由于肿瘤细胞起源的多样性，其分化的具体指标亦各不相同，一般包括形态与功能的分化、增殖
