产品货号:jlcR6989 英文名称:G6PDH 中文名称:己糖6磷酸脱氢酶抗体 别 名:6 phosphogluconolactonase; 6-phosphogluconolactonase; 6PGL; H6PD; DKFZp686A01246; G6PD H form; G6PDH; G6PE_HUMAN; GDH; H6PD; GDH/6PGL endoplasmic bifunctional protein; Glucose 1 dehydrogenase; Glucose 6 phosphate dehydrogenase salivary; Glucose dehyrogenase; Gpd1; H6pd; Hexose 6 phosphate dehydrogenase; Hexose-6-phosphate dehydrogenase; MGC87643. 研究领域:肿瘤 细胞生物 神经生物学 信号转导 生长因子和激素 抗体来源:Rabbit 克隆类型:Polyclonal 交叉反应: Human, Mouse, Rat, Dog, Horse, Rabbit, 产品应用:ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 (石蜡切片需做抗原修复) not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. 分 子 量:85kDa 细胞定位:细胞浆 性 状:Lyophilized or Liquid 浓 度:1mg/ml 免 疫 原:KLH conjugated synthetic peptide derived from human G6PDH:321-420/791 亚 型:IgG 纯化方法:affinity purified by Protein A 储 存 液:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. 保存条件:Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. PubMed:PubMed 产品介绍background: H6PD (hexose-6-phosphate dehydrogenase, GDH/6PGL endoplasmic bifunctional protein) is a 789 amino acid protein encoded by the human gene H6PD. The N-terminal section of H6PD belongs to the glucose-6-phosphate dehydrogenase family, while the C-terminal section belongs to the glucosamine/galactosamine-6-phosphate isomerase family, 6-phosphogluconolactonase subfamily. H6PD is responsible primarily for the oxidation of glucose-6-phosphate and glucose. It also oxidizes other hexose-6-phosphates. H6PD catalyzes the conversion of glucose 6-phosphate to 6-phosphogluconolactone within the lumen of the endoplasmic reticulum, thereby generating reduced nicotinamide adenine dinucleotide phosphate. Reduced nicotinamide adenine dinucleotide phosphate is a necessary cofactor for the reductase activity of 11∫-hydroxysteroid dehydrogenase type 1, which converts hormonally inactive cortisone to active cortisol (in rodents, 11-dehydrocorticosterone to corticosterone).
Function: Oxidizes glucose-6-phosphate and glucose, as well as other hexose-6-phosphates.
Tissue Specificity: Present in most tissues examined, strongest in liver.
DISEASE: Defects in H6PD are a cause of cortisone reductase deficiency (CRD) [MIM:604931]. In CRD, activation of cortisone to cortisol does not occur, resulting in adrenocorticotropin-mediated androgen excess and a phenotype resembling polycystic ovary syndrome (PCOS).
Similarity: In the N-terminal section; belongs to the glucose-6-phosphate dehydrogenase family. In the C-terminal section; belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.
SWISS: O95336
Gene ID: 9563
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.