产品货号 :jlcR23008 英文名称 :IL-12 中文名称 :白介素12抗体 别 名 :IL12; IL-12; CLMF p35; CLMF1; CTL maturation factor (TcMF); Cytotoxic lymphocyte maturation factor 1; Cytotoxic lymphocyte maturation factor 35 kDa subunit; IL 12 subunit p35; IL12A; Interleukin 12 alpha chain; Interleukin 12 p35; Interleukin 12A; Natural killer cell stimulatory factor 1; CLMF; CLMF p35; Cytotoxic lymphocyte maturation factor 35 kDa subunit; IL-12 subunit p35; IL-12A; IL12 subunit p35; IL12A; IL12A_HUMAN; Interleukin 12 p35; Interleukin 12A; Interleukin-12 subunit alpha; NFSK; NK cell stimulatory factor chain 1; NKSF1. NK cell stimulatory factor chain 1; NKSF1; p35; IL12A_MOUSE. 研究领域 :肿瘤 细胞生物 免疫学 生长因子和激素 抗体来源 :Rabbit 克隆类型 :Polyclonal 交叉反应 : Mouse, Rat, 产品应用 : WB=1:500-2000 ELISA=1:500-1000 Flow-Cyt=3ug/Test not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. 分 子 量 :22kDa 细胞定位 : 分泌型蛋白 性 状 : Lyophilized or Liquid 浓 度 : 1mg/ml 免 疫 原 : KLH conjugated synthetic peptide derived from mouse IL-12:21-100/215 亚 型 : IgG 纯化方法 : affinity purified by Protein A 储 存 液 : 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. 保存条件 : Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. PubMed : PubMed 产品介绍 : IL-12 protein is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract.
Function: Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC.
Subunit: Heterodimer with IL12B; disulfide-linked. The heterodimer is known as interleukin IL-12.
Subcellular Location: Secreted.
Similarity: Belongs to the IL-6 superfamily.
SWISS: P43431
Gene ID: 16159
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.