产品货号:jlcR1427 英文名称 :IRAK2 中文名称 :白介素-1受体相关激酶2抗体 别 名 :Interleukin 1 receptor associated kinase like 2; il1rak2; Interleukin 1 receptor associated kinase 2; Interleukin-1 receptor-associated kinase-like 2; IRAK 2; IRAK-2; Irak2; IRAK2_HUMAN; MGC150550. 研究领域 :细胞生物 免疫学 信号转导 激酶和磷酸酶 抗体来源 :Rabbit 克隆类型 :Polyclonal 交叉反应 : Human, Mouse, Rat, 产品应用 :ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 (石蜡切片需做抗原修复) not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. 分 子 量 :69kDa 细胞定位 :细胞核 细胞浆 细胞膜 性 状 :Lyophilized or Liquid 浓 度 :1mg/ml 免 疫 原 :KLH conjugated synthetic peptide derived from human IRAK2:21-150/625 亚 型 :IgG 纯化方法 :affinity purified by Protein A 储 存 液 :0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. 保存条件 :Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. PubMed :PubMed 产品介绍 : IRAK or Interleukin-1 Receptor-associated Kinase 1, is one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. This protein is partially responsible for IL1-induced upregulation of the ubiquitous transcription factor NF-kappa B.
Function: Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization.
Subunit: Interacts with MYD88. IL-1 stimulation leads to the formation of a signaling complex which dissociates from the IL-1 receptor following the binding of PELI1.
Tissue Specificity: Expressed in spleen, thymus, prostate, lung, liver, skeletal muscle, kidney, pancreas and peripheral blood leukocytes.
Similarity: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily. Contains 1 death domain. Contains 1 protein kinase domain.
SWISS: O43187
Gene ID: 3656
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.